GO Annotations Graph

• Symbol: Ptpn1
• Name: protein tyrosine phosphatase, non-receptor type 1
• ID: MGI:97805

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	TAS	Reactome:R-MMU-1169229
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	TAS	Reactome:R-MMU-210644
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:96001
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IMP	J:129555
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:219081
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169229
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-210644
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:197143
Cellular Component	GO:0005769	early endosome	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	NAS	J:219081
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0031904	endosome lumen	IDA	J:197143
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:241516
Cellular Component	GO:0097443	sorting endosome	IDA	J:197143
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:0038020	insulin receptor recycling	IMP	J:129555
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:96001
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	IMP	J:217999
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:219081
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:197143
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IMP	J:219081
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IBA	J:265628
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI	J:197143
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IMP	J:88185
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IBA	J:265628
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IGI	J:197143
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	ISO	J:164563
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	IMP	J:88185
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:217999
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:2000646	positive regulation of receptor catabolic process	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:96001
Biological Process	GO:0030100	regulation of endocytosis	ISO	J:164563
Biological Process	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0033157	regulation of intracellular protein transport	ISO	J:164563
Biological Process	GO:0009966	regulation of signal transduction	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:217999