GO Annotations Graph

• Symbol: Ptpn2
• Name: protein tyrosine phosphatase, non-receptor type 2
• ID: MGI:97806

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:109622
Molecular Function	GO:0005515	protein binding	IPI	J:223391
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IMP	J:88185
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	TAS	Reactome:R-MMU-210637
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:96001
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0097677	STAT family protein binding	IPI	J:223391
Molecular Function	GO:0019905	syntaxin binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	ISO	J:164563
Cellular Component	GO:0031904	endosome lumen	IDA	J:196641
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-210637
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:219081
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:223391
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0030183	B cell differentiation	IMP	J:42595
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:42595
Biological Process	GO:0042593	glucose homeostasis	IMP	J:169644
Biological Process	GO:0038020	insulin receptor recycling	IDA	J:96001
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:96001
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0050922	negative regulation of chemotaxis	IMP	J:88185
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:96360
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:90541
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP	J:169644
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP	J:196641
Biological Process	GO:1902206	negative regulation of interleukin-2-mediated signaling pathway	IMP	J:115366
Biological Process	GO:1902206	negative regulation of interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1902215	negative regulation of interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1902215	negative regulation of interleukin-4-mediated signaling pathway	IMP	J:197516
Biological Process	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway	IMP	J:169644
Biological Process	GO:0010888	negative regulation of lipid storage	IMP	J:169644
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	IMP	J:109622
Biological Process	GO:0045650	negative regulation of macrophage differentiation	IMP	J:109622
Biological Process	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP	J:88185
Biological Process	GO:1902233	negative regulation of positive thymic T cell selection	IMP	J:184426
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	IMP	J:219081
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	IMP	J:184426
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IPI	J:223391
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:96360
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	IMP	J:115366
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	IMP	J:197518
Biological Process	GO:0060336	negative regulation of type II interferon-mediated signaling pathway	IMP	J:197518
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	IMP	J:197516
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IMP	J:88185
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IBA	J:265628
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:219081
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IMP	J:169644
Biological Process	GO:1903899	positive regulation of PERK-mediated unfolded protein response	IMP	J:219081
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:96001
Biological Process	GO:0006470	protein dephosphorylation	IGI	J:223391
Biological Process	GO:0006470	protein dephosphorylation	IDA	J:223391
Biological Process	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	IMP	J:42595