GO Annotations Graph

• Symbol: Rac1
• Name: Rac family small GTPase 1
• ID: MGI:97845

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0003925	G protein activity	IEA	J:72245
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IBA	J:265628
Molecular Function	GO:0005525	GTP binding	IDA	J:98248
Molecular Function	GO:0005525	GTP binding	IDA	J:85182
Molecular Function	GO:0005525	GTP binding	IDA	J:203580
Molecular Function	GO:0005525	GTP binding	IDA	J:86235
Molecular Function	GO:0005525	GTP binding	ISO	J:93907
Molecular Function	GO:0005525	GTP binding	ISO	J:200103
Molecular Function	GO:0030742	GTP-dependent protein binding	IPI	J:113906
Molecular Function	GO:0003924	GTPase activity	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISO	J:241798
Molecular Function	GO:0003924	GTPase activity	IDA	J:80946
Molecular Function	GO:0003924	GTPase activity	IDA	J:82578
Molecular Function	GO:0003924	GTPase activity	IDA	J:91862
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:157023
Molecular Function	GO:0005515	protein binding	IPI	J:189982
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:169711
Molecular Function	GO:0005515	protein binding	IPI	J:213034
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:143595
Molecular Function	GO:0005515	protein binding	IPI	J:219617
Molecular Function	GO:0005515	protein binding	IPI	J:219617
Molecular Function	GO:0005515	protein binding	IPI	J:261829
Molecular Function	GO:0005515	protein binding	IPI	J:131850
Molecular Function	GO:0005515	protein binding	IPI	J:133183
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0005515	protein binding	IPI	J:4309
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0005515	protein binding	IPI	J:86309
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0051022	Rho GDP-dissociation inhibitor binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0031996	thioesterase binding	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IDA	J:100216
Cellular Component	GO:0005737	cytoplasm	IDA	J:219617
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:79013
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:81328
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:85182
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:81328
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:81328
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:81328
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0031901	early endosome membrane	IDA	J:219617
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0060091	kinocilium	IDA	J:195272
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:261829
Cellular Component	GO:0030027	lamellipodium	IDA	J:85182
Cellular Component	GO:0030027	lamellipodium	IDA	J:87902
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:87902
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:219617
Cellular Component	GO:0000242	pericentriolar material	IDA	J:195272
Cellular Component	GO:0001891	phagocytic cup	IDA	J:182420
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:219617
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421142
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421144
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421147
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421148
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5625893
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5663241
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5665656
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8981447
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9033341
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:81328
Cellular Component	GO:0005886	plasma membrane	IDA	J:81328
Cellular Component	GO:0098794	postsynapse	ISO	J:164563
Cellular Component	GO:0055038	recycling endosome membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IDA	J:182420
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:73065
Biological Process	GO:0007015	actin filament organization	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	IBA	J:265628
Biological Process	GO:0030041	actin filament polymerization	IDA	J:193444
Biological Process	GO:0048532	anatomical structure arrangement	IMP	J:157099
Biological Process	GO:0048532	anatomical structure arrangement	IMP	J:157099
Biological Process	GO:0086098	angiotensin-activated signaling pathway involved in heart process	IDA	J:298386
Biological Process	GO:0002093	auditory receptor cell morphogenesis	IMP	J:157099
Biological Process	GO:0002093	auditory receptor cell morphogenesis	IMP	J:157099
Biological Process	GO:0007411	axon guidance	IMP	J:121201
Biological Process	GO:0007411	axon guidance	IMP	J:121201
Biological Process	GO:0045453	bone resorption	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IDA	J:87902
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0016477	cell migration	IDA	J:98248
Biological Process	GO:0048870	cell motility	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:157099
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:157099
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0021894	cerebral cortex GABAergic interneuron development	IGI	J:210135
Biological Process	GO:0021799	cerebral cortex radially oriented cell migration	IMP	J:121201
Biological Process	GO:0006935	chemotaxis	ISO	J:155856
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:157099
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:157099
Biological Process	GO:0030865	cortical cytoskeleton organization	IBA	J:265628
Biological Process	GO:0007010	cytoskeleton organization	IDA	J:87902
Biological Process	GO:0016358	dendrite development	IDA	J:79013
Biological Process	GO:0048813	dendrite morphogenesis	IGI	J:159217
Biological Process	GO:0071542	dopaminergic neuron differentiation	IGI	J:144081
Biological Process	GO:0021831	embryonic olfactory bulb interneuron precursor migration	IMP	J:121201
Biological Process	GO:0006897	endocytosis	IDA	J:81687
Biological Process	GO:0043652	engulfment of apoptotic cell	IDA	J:170006
Biological Process	GO:0043652	engulfment of apoptotic cell	IBA	J:265628
Biological Process	GO:0003382	epithelial cell morphogenesis	IMP	J:157099
Biological Process	GO:0003382	epithelial cell morphogenesis	IMP	J:157099
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IBA	J:265628
Biological Process	GO:0030900	forebrain development	IDA	J:143541
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IGI	J:168922
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IGI	J:168922
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IGI	J:210135
Biological Process	GO:0006972	hyperosmotic response	IDA	J:85182
Biological Process	GO:1904936	interneuron migration	IMP	J:121201
Biological Process	GO:0030032	lamellipodium assembly	ISO	J:164563
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:98248
Biological Process	GO:0030032	lamellipodium assembly	TAS	J:79193
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0051668	localization within membrane	ISO	J:164563
Biological Process	GO:0002551	mast cell chemotaxis	ISO	J:155856
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	IMP	J:144081
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	IMP	J:192848
Biological Process	GO:0008045	motor neuron axon guidance	IBA	J:265628
Biological Process	GO:0010764	negative regulation of fibroblast migration	ISO	J:164563
Biological Process	GO:0032707	negative regulation of interleukin-23 production	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:261829
Biological Process	GO:0001764	neuron migration	IMP	J:121201
Biological Process	GO:0048812	neuron projection morphogenesis	IGI	J:171436
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IGI	J:171436
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:182420
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IDA	J:84642
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0060999	positive regulation of dendritic spine development	IGI	J:222722
Biological Process	GO:0060999	positive regulation of dendritic spine development	IMP	J:222722
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:155856
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:196706
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:93907
Biological Process	GO:0031116	positive regulation of microtubule polymerization	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	IMP	J:151789
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:2000386	positive regulation of ovarian follicle development	IMP	J:283201
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:100216
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0072659	protein localization to plasma membrane	IDA	J:194204
Biological Process	GO:0016601	Rac protein signal transduction	ISO	J:155856
Biological Process	GO:0016601	Rac protein signal transduction	IBA	J:265628
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	IMP	J:220364
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:0022604	regulation of cell morphogenesis	IGI	J:210135
Biological Process	GO:0008360	regulation of cell shape	IBA	J:265628
Biological Process	GO:0008361	regulation of cell size	ISO	J:164563
Biological Process	GO:0070376	regulation of ERK5 cascade	IDA	J:298386
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:219617
Biological Process	GO:0010591	regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0014041	regulation of neuron maturation	IGI	J:210135
Biological Process	GO:2001222	regulation of neuron migration	IMP	J:121201
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IGI	J:222722
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IMP	J:222722
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	IMP	J:283201
Biological Process	GO:0060263	regulation of respiratory burst	ISO	J:164563
Biological Process	GO:0051492	regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0097178	ruffle assembly	ISO	J:164563
Biological Process	GO:0097178	ruffle assembly	IMP	J:182420
Biological Process	GO:0031529	ruffle organization	ISO	J:93907
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	ISO	J:155856
Biological Process	GO:0007264	small GTPase mediated signal transduction	ISO	J:164563
Biological Process	GO:0007264	small GTPase mediated signal transduction	IDA	J:82578
Biological Process	GO:0007264	small GTPase mediated signal transduction	IDA	J:205847
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IMP	J:151789
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IDA	J:130925
Biological Process	GO:0051932	synaptic transmission, GABAergic	IGI	J:210135
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IGI	J:144081