GO Annotations Graph

• Symbol: Raf1
• Name: v-raf-leukemia viral oncogene 1
• ID: MGI:97847

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010856	adenylate cyclase activator activity	ISO	J:155856
Molecular Function	GO:0008179	adenylate cyclase binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IDA	J:1586
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IDA	J:327412
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:184683
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:248219
Molecular Function	GO:0005515	protein binding	IPI	J:161180
Molecular Function	GO:0005515	protein binding	IPI	J:183162
Molecular Function	GO:0005515	protein binding	IPI	J:247467
Molecular Function	GO:0005515	protein binding	IPI	J:104536
Molecular Function	GO:0005515	protein binding	IPI	J:88364
Molecular Function	GO:0005515	protein binding	IPI	J:102860
Molecular Function	GO:0030295	protein kinase activator activity	IMP	J:326637
Molecular Function	GO:0030295	protein kinase activator activity	IMP	J:326639
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:1586
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:327412
Molecular Function	GO:0004672	protein kinase activity	TAS	J:55090
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:326639
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:326637
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	IPI	J:117391
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:124964
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	J:55090
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:124964
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:124964
Cellular Component	GO:0005886	plasma membrane	TAS	J:55090
Cellular Component	GO:0031143	pseudopodium	IDA	J:85273
Biological Process	GO:0007190	activation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IGI	J:61360
Biological Process	GO:0071550	death-inducing signaling complex assembly	IMP	J:104536
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:104536
Biological Process	GO:0060324	face development	IGI	J:144862
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:326639
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	IMP	J:180723
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:327178
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:307414
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IMP	J:104536
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:180723
Biological Process	GO:0035556	intracellular signal transduction	TAS	J:55090
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:104536
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:104536
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	IMP	J:68953
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:180723
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:180723
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0035994	response to muscle stretch	IMP	J:163557
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:196225
Biological Process	GO:0048538	thymus development	IGI	J:144862
Biological Process	GO:0030878	thyroid gland development	IGI	J:144862
Biological Process	GO:0044342	type B pancreatic cell proliferation	IMP	J:326637