GO Annotations Graph

• Symbol: Rag1
• Name: recombination activating 1
• ID: MGI:97848

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:1990238	double-stranded DNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0004519	endonuclease activity	IMP	J:159059
Molecular Function	GO:0004519	endonuclease activity	IMP	J:159089
Molecular Function	GO:0042393	histone binding	IDA	J:158989
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:245257
Molecular Function	GO:0042802	identical protein binding	IPI	J:159059
Molecular Function	GO:0046872	metal ion binding	IMP	J:159089
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:159059
Molecular Function	GO:0005515	protein binding	IPI	J:245396
Molecular Function	GO:0005515	protein binding	IPI	J:245257
Molecular Function	GO:0005515	protein binding	IPI	J:173031
Molecular Function	GO:0005515	protein binding	IPI	J:173031
Molecular Function	GO:0005515	protein binding	IPI	J:173031
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:159276
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:159059
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:159059
Molecular Function	GO:0043565	sequence-specific DNA binding	IMP	J:159089
Molecular Function	GO:0043565	sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:158989
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:88204
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:159076
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:159076
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:158989
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:88204
Molecular Function	GO:0008270	zinc ion binding	IDA	J:159276
Cellular Component	GO:0097519	DNA recombinase complex	IBA	J:265628
Cellular Component	GO:1905347	endodeoxyribonuclease complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8865728
Cellular Component	GO:0005634	nucleus	IDA	J:16553
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0002250	adaptive immune response	IBA	J:265628
Biological Process	GO:0002250	adaptive immune response	IMP	J:186687
Biological Process	GO:0030183	B cell differentiation	IMP	J:1934
Biological Process	GO:0030183	B cell differentiation	IDA	J:76135
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006310	DNA recombination	TAS	J:82340
Biological Process	GO:0010390	histone monoubiquitination	IBA	J:265628
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:96628
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IGI	J:140121
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:96628
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:1934
Biological Process	GO:0002331	pre-B cell allelic exclusion	IMP	J:149451
Biological Process	GO:0002331	pre-B cell allelic exclusion	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	IDA	J:88204
Biological Process	GO:2000822	regulation of behavioral fear response	ISO	J:155856
Biological Process	GO:0045580	regulation of T cell differentiation	IGI	J:140121
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:1934
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:41239
Biological Process	GO:0043029	T cell homeostasis	IGI	J:140121
Biological Process	GO:0048538	thymus development	IGI	J:140121
Biological Process	GO:0033151	V(D)J recombination	ISO	J:164563
Biological Process	GO:0033151	V(D)J recombination	IMP	J:158989
Biological Process	GO:0033151	V(D)J recombination	IMP	J:1934
Biological Process	GO:0033151	V(D)J recombination	IMP	J:16553
Biological Process	GO:0033151	V(D)J recombination	IMP	J:159089
Biological Process	GO:0033151	V(D)J recombination	IBA	J:265628
Biological Process	GO:0033151	V(D)J recombination	IGI	J:10580
Biological Process	GO:0008542	visual learning	ISO	J:155856