GO Annotations Graph

• Symbol: Rb1
• Name: RB transcriptional corepressor 1
• ID: MGI:97874

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:113669
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:111352
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0061676	importin-alpha family protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:168216
Molecular Function	GO:0005515	protein binding	IPI	J:116389
Molecular Function	GO:0005515	protein binding	IPI	J:171241
Molecular Function	GO:0005515	protein binding	IPI	J:279973
Molecular Function	GO:0005515	protein binding	IPI	J:24886
Molecular Function	GO:0005515	protein binding	IPI	J:45398
Molecular Function	GO:0005515	protein binding	IPI	J:150653
Molecular Function	GO:0005515	protein binding	IPI	J:163144
Molecular Function	GO:0005515	protein binding	IPI	J:148074
Molecular Function	GO:0005515	protein binding	IPI	J:98743
Molecular Function	GO:0005515	protein binding	IPI	J:78851
Molecular Function	GO:0005515	protein binding	IPI	J:100923
Molecular Function	GO:0005515	protein binding	IPI	J:92967
Molecular Function	GO:0005515	protein binding	IPI	J:99862
Molecular Function	GO:0005515	protein binding	IPI	J:98743
Molecular Function	GO:0005515	protein binding	IPI	J:155508
Molecular Function	GO:0005515	protein binding	IPI	J:53930
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:175343
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IBA	J:265628
Cellular Component	GO:0061793	chromatin lock complex	ISO	J:164563
Cellular Component	GO:0008024	cyclin/CDK positive transcription elongation factor complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985623
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:279973
Cellular Component	GO:0005634	nucleus	IDA	J:53930
Cellular Component	GO:0005634	nucleus	IDA	J:98743
Cellular Component	GO:0005634	nucleus	IDA	J:95106
Cellular Component	GO:0005634	nucleus	IDA	J:108349
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0035189	Rb-E2F complex	IDA	J:279973
Cellular Component	GO:0035189	Rb-E2F complex	ISO	J:164563
Cellular Component	GO:0035189	Rb-E2F complex	IDA	J:175343
Cellular Component	GO:0035189	Rb-E2F complex	IBA	J:265628
Cellular Component	GO:0005819	spindle	IDA	J:93217
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:53930
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:257024
Biological Process	GO:0006915	apoptotic process	IMP	J:139039
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0051301	cell division	IMP	J:98518
Biological Process	GO:0051301	cell division	IMP	J:98518
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	IBA	J:265628
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	IMP	J:113043
Biological Process	GO:0008283	cell population proliferation	IMP	J:98518
Biological Process	GO:0008283	cell population proliferation	IMP	J:98518
Biological Process	GO:0008283	cell population proliferation	IMP	J:98518
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:139039
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IMP	J:210952
Biological Process	GO:0002062	chondrocyte differentiation	IDA	J:139039
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0051276	chromosome organization	ISO	J:164563
Biological Process	GO:0048565	digestive tract development	IMP	J:119916
Biological Process	GO:0048565	digestive tract development	IMP	J:119916
Biological Process	GO:0043353	enucleate erythrocyte differentiation	IGI	J:95106
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:119916
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:97648
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:113043
Biological Process	GO:0034349	glial cell apoptotic process	IMP	J:71535
Biological Process	GO:0034349	glial cell apoptotic process	IMP	J:71535
Biological Process	GO:0014009	glial cell proliferation	IGI	J:80411
Biological Process	GO:0097284	hepatocyte apoptotic process	IMP	J:71535
Biological Process	GO:0031507	heterochromatin formation	ISO	J:164563
Biological Process	GO:0034088	maintenance of mitotic sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0045445	myoblast differentiation	ISO	J:164563
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:155856
Biological Process	GO:0045786	negative regulation of cell cycle	IMP	J:84407
Biological Process	GO:0030308	negative regulation of cell growth	IDA	J:279973
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:98518
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:151181
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:92455
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:119916
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IMP	J:113043
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:216069
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:216069
Biological Process	GO:0060253	negative regulation of glial cell proliferation	IGI	J:80411
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:257024
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	IGI	J:32537
Biological Process	GO:1904761	negative regulation of myofibroblast differentiation	IMP	J:257024
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:119916
Biological Process	GO:1902948	negative regulation of tau-protein kinase activity	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:175343
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:78851
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:26103
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:100923
Biological Process	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	IGI	J:175343
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:113043
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:71535
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:71535
Biological Process	GO:0030182	neuron differentiation	IMP	J:113043
Biological Process	GO:0042551	neuron maturation	IMP	J:113043
Biological Process	GO:0031175	neuron projection development	IBA	J:265628
Biological Process	GO:0031175	neuron projection development	IMP	J:113043
Biological Process	GO:1904028	positive regulation of collagen fibril organization	IMP	J:257024
Biological Process	GO:1903055	positive regulation of extracellular matrix organization	IMP	J:257024
Biological Process	GO:0045651	positive regulation of macrophage differentiation	IGI	J:95106
Biological Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:98743
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:98743
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:210434
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98743
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:210434
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98743
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:216069
Biological Process	GO:0071459	protein localization to chromosome, centromeric region	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:99580
Biological Process	GO:0001558	regulation of cell growth	IGI	J:216069
Biological Process	GO:0043550	regulation of lipid kinase activity	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	IMP	J:97648
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IEA	J:72247
Biological Process	GO:0031134	sister chromatid biorientation	ISO	J:164563
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0035914	skeletal muscle cell differentiation	IGI	J:94087
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:119916
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:94087
Biological Process	GO:0001894	tissue homeostasis	IGI	J:216069
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:210434
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:210434