GO Annotations Graph

• Symbol: Ren2
• Name: renin 2 tandem duplication of Ren1
• ID: MGI:97899

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:150694
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0016504	peptidase activator activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:150694
Biological Process	GO:0002003	angiotensin maturation	ISO	J:164563
Biological Process	GO:0002003	angiotensin maturation	ISO	J:155856
Biological Process	GO:0002003	angiotensin maturation	IBA	J:265628
Biological Process	GO:0010467	gene expression	IMP	J:278974
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0045777	positive regulation of blood pressure	IDA	J:150694
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0043408	regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051591	response to cAMP	ISO	J:155856
Biological Process	GO:0070305	response to cGMP	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856