GO Annotations Graph

• Symbol: Rpe65
• Name: retinal pigment epithelium 65
• ID: MGI:98001

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	ISO	J:155856
Molecular Function	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IBA	J:265628
Molecular Function	GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	ISO	J:164563
Molecular Function	GO:0003834	beta-carotene 15,15'-dioxygenase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016853	isomerase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:173770
Molecular Function	GO:0050251	retinol isomerase activity	IBA	J:265628
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:298908
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:298908
Cellular Component	GO:0005886	plasma membrane	IDA	J:298908
Biological Process	GO:0071257	cellular response to electrical stimulus	IMP	J:166679
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:121152
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0003407	neural retina development	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:76856
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:166679
Biological Process	GO:0001895	retina homeostasis	ISO	J:164563
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:166679
Biological Process	GO:0042574	retinal metabolic process	ISO	J:155856
Biological Process	GO:0042574	retinal metabolic process	IBA	J:265628
Biological Process	GO:0042574	retinal metabolic process	IMP	J:76856
Biological Process	GO:0001523	retinoid metabolic process	ISO	J:164563
Biological Process	GO:0042572	retinol metabolic process	ISO	J:155856
Biological Process	GO:0007601	visual perception	IMP	J:76856
Biological Process	GO:1901827	zeaxanthin biosynthetic process	ISO	J:164563
Biological Process	GO:1901827	zeaxanthin biosynthetic process	IBA	J:265628