GO Annotations Graph

• Symbol: Polr2a
• Name: polymerase (RNA) II (DNA directed) polypeptide A
• ID: MGI:98086

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	IDA	J:185349
Molecular Function	GO:0003677	DNA binding	IDA	J:95384
Molecular Function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEA	J:72245
Molecular Function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEA	J:72247
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:161123
Molecular Function	GO:0005515	protein binding	IPI	J:200392
Molecular Function	GO:0005515	protein binding	IPI	J:186079
Molecular Function	GO:0005515	protein binding	IPI	J:245360
Molecular Function	GO:0005515	protein binding	IPI	J:206891
Molecular Function	GO:0005515	protein binding	IPI	J:185950
Molecular Function	GO:0005515	protein binding	IPI	J:86566
Molecular Function	GO:0005515	protein binding	IPI	J:183914
Molecular Function	GO:0001055	RNA polymerase II activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0000428	DNA-directed RNA polymerase complex	IEA	J:60000
Cellular Component	GO:0000791	euchromatin	IDA	J:185349
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5605301
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617960
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619411
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619424
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619428
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619430
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619434
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619436
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619437
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619438
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619440
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5621004
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5621012
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5693628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:231359
Cellular Component	GO:0005634	nucleus	ISO	J:101015
Cellular Component	GO:0005634	nucleus	ISO	J:86236
Cellular Component	GO:0000974	Prp19 complex	ISO	J:164563
Cellular Component	GO:0005665	RNA polymerase II, core complex	ISO	J:164563
Cellular Component	GO:0005665	RNA polymerase II, core complex	IBA	J:265628
Biological Process	GO:0006351	DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006353	DNA-templated transcription termination	ISO	J:164563
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:164563