GO Annotations Graph

• Symbol: Scn1a
• Name: sodium channel, voltage-gated, type I, alpha
• ID: MGI:98246

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IDA	J:235304
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IMP	J:113149
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IMP	J:113149
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:125694
Cellular Component	GO:0030424	axon	IDA	J:121969
Cellular Component	GO:0030424	axon	IDA	J:121969
Cellular Component	GO:0030424	axon	IDA	J:121969
Cellular Component	GO:0043194	axon initial segment	IDA	J:121969
Cellular Component	GO:0014704	intercalated disc	IDA	J:109097
Cellular Component	GO:0016020	membrane	IDA	J:121969
Cellular Component	GO:0016020	membrane	IDA	J:76457
Cellular Component	GO:0043025	neuronal cell body	IDA	J:125694
Cellular Component	GO:0043025	neuronal cell body	IDA	J:121969
Cellular Component	GO:0033268	node of Ranvier	IDA	J:121969
Cellular Component	GO:0033268	node of Ranvier	IDA	J:121969
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0030315	T-tubule	IDA	J:109097
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:127606
Biological Process	GO:0007628	adult walking behavior	IMP	J:121969
Biological Process	GO:0007628	adult walking behavior	IMP	J:125694
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IDA	J:235304
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:113149
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:113149
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:125694
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0050884	neuromuscular process controlling posture	IMP	J:113149
Biological Process	GO:0050884	neuromuscular process controlling posture	IMP	J:125694
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0019228	neuronal action potential	IMP	J:125694
Biological Process	GO:0019228	neuronal action potential	IMP	J:125694
Biological Process	GO:0019228	neuronal action potential	IMP	J:113149
Biological Process	GO:0019228	neuronal action potential	IMP	J:113149
Biological Process	GO:0019227	neuronal action potential propagation	IMP	J:121696
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:125694
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	IDA	J:235304
Biological Process	GO:0006814	sodium ion transport	IMP	J:113149
Biological Process	GO:0006814	sodium ion transport	IMP	J:113149
Biological Process	GO:0006814	sodium ion transport	IMP	J:125694
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247