Scn2a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Scn2a
sodium channel, voltage-gated, type II, alpha
MGI:98248

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043522	leucine zipper domain binding	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0005272	sodium channel activity	TAS	Reactome:R-MMU-9717445
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IMP	J:76457
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IDA	J:76457
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:125694
Cellular Component	GO:0043194	axon initial segment	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265799
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265799
Cellular Component	GO:0014704	intercalated disc	IDA	J:109097
Cellular Component	GO:0016020	membrane	IDA	J:76457
Cellular Component	GO:0016020	membrane	IDA	J:121969
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0033268	node of Ranvier	ISO	J:155856
Cellular Component	GO:0033270	paranode region of axon	IDA	J:109037
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:76457
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9717445
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:265799
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:265799
Cellular Component	GO:0034706	sodium channel complex	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:109097
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Cellular Component	GO:0001518	voltage-gated sodium channel complex	TAS	J:76457
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	IMP	J:76457
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0007613	memory	IMP	J:264736
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0007399	nervous system development	IMP	J:76457
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:76457
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:76457
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0006814	sodium ion transport	IDA	J:76457
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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