GO Annotations Graph

• Symbol: Scn2a
• Name: sodium channel, voltage-gated, type II, alpha
• ID: MGI:98248

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043522	leucine zipper domain binding	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0005272	sodium channel activity	TAS	Reactome:R-MMU-9717445
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IMP	J:76457
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IDA	J:76457
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:125694
Cellular Component	GO:0043194	axon initial segment	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265799
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265799
Cellular Component	GO:0014704	intercalated disc	IDA	J:109097
Cellular Component	GO:0016020	membrane	IDA	J:76457
Cellular Component	GO:0016020	membrane	IDA	J:121969
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0033268	node of Ranvier	ISO	J:155856
Cellular Component	GO:0033270	paranode region of axon	IDA	J:109037
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:76457
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9717445
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:265799
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:265799
Cellular Component	GO:0034706	sodium channel complex	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:109097
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Cellular Component	GO:0001518	voltage-gated sodium channel complex	TAS	J:76457
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	IMP	J:76457
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0007613	memory	IMP	J:264736
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0007399	nervous system development	IMP	J:76457
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:76457
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:76457
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0006814	sodium ion transport	IDA	J:76457
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247