GO Annotations Graph

• Symbol: Ccl4
• Name: C-C motif chemokine ligand 4
• ID: MGI:98261

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	ISO	J:155856
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:29873
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:232381
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:219149
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048245	eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0030595	leukocyte chemotaxis	ISO	J:155856
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:155856