GO Annotations Graph

• Symbol: Ccl5
• Name: C-C motif chemokine ligand 5
• ID: MGI:98262

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	IDA	J:169909
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	ISO	J:155856
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0046817	chemokine receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0042379	chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:4055
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:168000
Cellular Component	GO:0005615	extracellular space	IDA	J:232381
Cellular Component	GO:0005615	extracellular space	IDA	J:194920
Biological Process	GO:0031584	activation of phospholipase D activity	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048245	eosinophil chemotaxis	ISO	J:164563
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:197406
Biological Process	GO:0006887	exocytosis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:197406
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048247	lymphocyte chemotaxis	ISO	J:155856
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:0043922	negative regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	IMP	J:102878
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0042119	neutrophil activation	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	NAS	J:173704
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IC	J:102878
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:197406
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0031622	positive regulation of fever generation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0060754	positive regulation of mast cell chemotaxis	ISO	J:155856
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	IDA	J:172951
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0070234	positive regulation of T cell apoptotic process	ISO	J:164563
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ISO	J:164563
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ISO	J:155856
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	IBA	J:265628
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:200103
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0031269	pseudopodium assembly	ISO	J:155856
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:1901214	regulation of neuron death	ISO	J:164563
Biological Process	GO:0050863	regulation of T cell activation	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	IDA	J:4055
Biological Process	GO:0009636	response to toxic substance	ISO	J:164563
Biological Process	GO:0034612	response to tumor necrosis factor	IDA	J:4055
Biological Process	GO:0034341	response to type II interferon	ISO	J:155856
Biological Process	GO:0035688	T-helper 1 cell diapedesis	ISO	J:155856