GO Annotations Graph

• Symbol: Epha4
• Name: Eph receptor A4
• ID: MGI:98277

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0097161	DH domain binding	ISO	J:164563
Molecular Function	GO:0005003	ephrin receptor activity	IEA	J:72247
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:155856
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	IMP	J:117343
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	IMP	J:130934
Molecular Function	GO:0042802	identical protein binding	IPI	J:200429
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042731	PH domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:128698
Molecular Function	GO:0005515	protein binding	IPI	J:125703
Molecular Function	GO:0005515	protein binding	IPI	J:200429
Molecular Function	GO:0005515	protein binding	IPI	J:130934
Molecular Function	GO:0005515	protein binding	IPI	J:117343
Molecular Function	GO:0005515	protein binding	IPI	J:125703
Molecular Function	GO:0005515	protein binding	IPI	J:139754
Molecular Function	GO:0005515	protein binding	IPI	J:248205
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:333005
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	IDA	J:125703
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:117343
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:117343
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0031901	early endosome membrane	IDA	J:117343
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0030175	filopodium	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:81695
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:81695
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:81695
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:81695
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:81695
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:117343
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928621
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IEP	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IEP	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:138754
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0034332	adherens junction organization	IMP	J:276414
Biological Process	GO:0007628	adult walking behavior	IMP	J:82479
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007411	axon guidance	IGI	J:192361
Biological Process	GO:0007411	axon guidance	IMP	J:82479
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:214156
Biological Process	GO:0090102	cochlea development	IMP	J:276414
Biological Process	GO:0021957	corticospinal tract morphogenesis	IMP	J:50573
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048013	ephrin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0097156	fasciculation of motor neuron axon	IMP	J:133671
Biological Process	GO:0097155	fasciculation of sensory neuron axon	IMP	J:133671
Biological Process	GO:0008347	glial cell migration	ISO	J:155856
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:128698
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048681	negative regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0048681	negative regulation of axon regeneration	IMP	J:96567
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:1900038	negative regulation of cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IGI	J:214156
Biological Process	GO:0010977	negative regulation of neuron projection development	IDA	J:242550
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0072178	nephric duct morphogenesis	IGI	J:214811
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0106030	neuron projection fasciculation	IDA	J:242550
Biological Process	GO:0097485	neuron projection guidance	IDA	J:242550
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:64817
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IGI	J:214156
Biological Process	GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0048710	regulation of astrocyte differentiation	IMP	J:96567
Biological Process	GO:0050770	regulation of axonogenesis	IMP	J:96567
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IMP	J:117343
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:125703
Biological Process	GO:0043087	regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0043087	regulation of GTPase activity	IMP	J:130934
Biological Process	GO:1905244	regulation of modification of synaptic structure	ISO	J:155856
Biological Process	GO:1905244	regulation of modification of synaptic structure	IGI	J:214156
Biological Process	GO:1905806	regulation of synapse pruning	ISO	J:155856
Biological Process	GO:0098883	synapse pruning	IMP	J:81695
Biological Process	GO:0098883	synapse pruning	IDA	J:81695
Biological Process	GO:0098883	synapse pruning	IDA	J:81695
Biological Process	GO:0098883	synapse pruning	EXP	J:81695
Biological Process	GO:0098883	synapse pruning	IMP	J:81695
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	J:72247