GO Annotations Graph

• Symbol: Spi1
• Name: Spi-1 proto-oncogene
• ID: MGI:98282

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IMP	J:302467
Molecular Function	GO:0003682	chromatin binding	IMP	J:282485
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:302467
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:305999
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:294049
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:268259
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:247193
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:302468
Molecular Function	GO:0003677	DNA binding	IDA	J:169820
Molecular Function	GO:0003677	DNA binding	IDA	J:92671
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:294049
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:247193
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:302467
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:305999
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:268259
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:90964
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:76489
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:111308
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:111308
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:272739
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:100734
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:282485
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0051525	NFAT protein binding	IPI	J:180479
Molecular Function	GO:0005515	protein binding	IPI	J:113820
Molecular Function	GO:0005515	protein binding	IPI	J:175175
Molecular Function	GO:0005515	protein binding	IPI	J:108699
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:138413
Molecular Function	GO:0140311	protein sequestering activity	IMP	J:272739
Molecular Function	GO:0140311	protein sequestering activity	IMP	J:272739
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:100734
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:180479
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:202853
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:111308
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:180479
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:131309
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:2685
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0097677	STAT family protein binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:90824
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9616215
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-8865529
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:180479
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:111308
Cellular Component	GO:0005634	nucleus	IDA	J:92671
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IC	J:76489
Biological Process	GO:0060033	anatomical structure regression	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0098508	endothelial to hematopoietic transition	IEP	J:302458
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:39856
Biological Process	GO:0002316	follicular B cell differentiation	IGI	J:275800
Biological Process	GO:0002314	germinal center B cell differentiation	IGI	J:275800
Biological Process	GO:0030851	granulocyte differentiation	IDA	J:76489
Biological Process	GO:0002327	immature B cell differentiation	IGI	J:247785
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:305999
Biological Process	GO:0030098	lymphocyte differentiation	IDA	J:76489
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IMP	J:39856
Biological Process	GO:0030225	macrophage differentiation	IDA	J:76489
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:59927
Biological Process	GO:0002573	myeloid leukocyte differentiation	ISO	J:164563
Biological Process	GO:0002573	myeloid leukocyte differentiation	IMP	J:39856
Biological Process	GO:1904178	negative regulation of adipose tissue development	IMP	J:302459
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:302467
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:272739
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:294049
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:249136
Biological Process	GO:0045347	negative regulation of MHC class II biosynthetic process	IDA	J:169820
Biological Process	GO:0043314	negative regulation of neutrophil degranulation	IMP	J:282485
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	IMP	J:282485
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:100734
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:282485
Biological Process	GO:0090402	oncogene-induced cell senescence	IDA	J:297324
Biological Process	GO:1904238	pericyte cell differentiation	IMP	J:256251
Biological Process	GO:1905036	positive regulation of antifungal innate immune response	IMP	J:282485
Biological Process	GO:0045579	positive regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:89650
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:249136
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IMP	J:249136
Biological Process	GO:1902895	positive regulation of miRNA transcription	IDA	J:225404
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:2000529	positive regulation of myeloid dendritic cell chemotaxis	IMP	J:294049
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	IDA	J:297324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:247193
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:294049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:305999
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:275800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:268259
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:180479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:180479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:272739
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:247193
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:302467
Biological Process	GO:0002572	pro-T cell differentiation	IMP	J:302467
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	IMP	J:272739
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:90964
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:76489
Biological Process	GO:0045646	regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:1905453	regulation of myeloid progenitor cell differentiation	IMP	J:302458
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:111308
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:150463
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	IDA	J:302467
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:294049
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0001944	vasculature development	IMP	J:101493