Spi1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Spi1
Spi-1 proto-oncogene
MGI:98282

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IMP	J:302467
Molecular Function	GO:0003682	chromatin binding	IMP	J:282485
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:302467
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:305999
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:294049
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:268259
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:247193
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:302468
Molecular Function	GO:0003677	DNA binding	IDA	J:169820
Molecular Function	GO:0003677	DNA binding	IDA	J:92671
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:294049
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:247193
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:302467
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:305999
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:268259
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:90964
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:76489
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:180479
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:111308
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:111308
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:272739
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:100734
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:282485
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0051525	NFAT protein binding	IPI	J:180479
Molecular Function	GO:0005515	protein binding	IPI	J:113820
Molecular Function	GO:0005515	protein binding	IPI	J:175175
Molecular Function	GO:0005515	protein binding	IPI	J:108699
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:138413
Molecular Function	GO:0140311	protein sequestering activity	IMP	J:272739
Molecular Function	GO:0140311	protein sequestering activity	IMP	J:272739
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:100734
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:180479
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:202853
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:111308
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:180479
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:131309
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:2685
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:204719
Molecular Function	GO:0097677	STAT family protein binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:90824
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9616215
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-8865529
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:180479
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:111308
Cellular Component	GO:0005634	nucleus	IDA	J:92671
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IC	J:76489
Biological Process	GO:0060033	anatomical structure regression	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0098508	endothelial to hematopoietic transition	IEP	J:302458
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:39856
Biological Process	GO:0002316	follicular B cell differentiation	IGI	J:275800
Biological Process	GO:0002314	germinal center B cell differentiation	IGI	J:275800
Biological Process	GO:0030851	granulocyte differentiation	IDA	J:76489
Biological Process	GO:0002327	immature B cell differentiation	IGI	J:247785
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:305999
Biological Process	GO:0030098	lymphocyte differentiation	IDA	J:76489
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IMP	J:39856
Biological Process	GO:0030225	macrophage differentiation	IDA	J:76489
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:59927
Biological Process	GO:0002573	myeloid leukocyte differentiation	ISO	J:164563
Biological Process	GO:0002573	myeloid leukocyte differentiation	IMP	J:39856
Biological Process	GO:1904178	negative regulation of adipose tissue development	IMP	J:302459
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:302467
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:272739
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:294049
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:249136
Biological Process	GO:0045347	negative regulation of MHC class II biosynthetic process	IDA	J:169820
Biological Process	GO:0043314	negative regulation of neutrophil degranulation	IMP	J:282485
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	IMP	J:282485
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:100734
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:282485
Biological Process	GO:0090402	oncogene-induced cell senescence	IDA	J:297324
Biological Process	GO:1904238	pericyte cell differentiation	IMP	J:256251
Biological Process	GO:1905036	positive regulation of antifungal innate immune response	IMP	J:282485
Biological Process	GO:0045579	positive regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:89650
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:249136
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IMP	J:249136
Biological Process	GO:1902895	positive regulation of miRNA transcription	IDA	J:225404
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:2000529	positive regulation of myeloid dendritic cell chemotaxis	IMP	J:294049
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	IDA	J:297324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:247193
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:294049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:305999
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:275800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:268259
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:180479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:180479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:272739
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:247193
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:302467
Biological Process	GO:0002572	pro-T cell differentiation	IMP	J:302467
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	IMP	J:272739
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:90964
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:76489
Biological Process	GO:0045646	regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:1905453	regulation of myeloid progenitor cell differentiation	IMP	J:302458
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:111308
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:150463
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	IDA	J:302467
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:294049
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0001944	vasculature development	IMP	J:101493

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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