GO Annotations Graph

• Symbol: Shc1
• Name: src homology 2 domain-containing transforming protein C1
• ID: MGI:98296

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:177164
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0048408	epidermal growth factor binding	IPI	J:93419
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:248220
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:81182
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:327223
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:164563
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:200379
Molecular Function	GO:0005515	protein binding	IPI	J:206901
Molecular Function	GO:0005515	protein binding	IPI	J:133325
Molecular Function	GO:0005515	protein binding	IPI	J:277874
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:230032
Molecular Function	GO:0005515	protein binding	IPI	J:93419
Molecular Function	GO:0005515	protein binding	IPI	J:113920
Molecular Function	GO:0005515	protein binding	IPI	J:200359
Molecular Function	GO:0005515	protein binding	IPI	J:200360
Molecular Function	GO:0005515	protein binding	IPI	J:200409
Molecular Function	GO:0005515	protein binding	IPI	J:212898
Molecular Function	GO:0005515	protein binding	IPI	J:85624
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:130626
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:81182
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:327223
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983294
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983313
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027266
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029147
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1248744
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1248753
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250472
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1250500
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9030473
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9034884
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9036937
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9036961
Cellular Component	GO:0010008	endosome membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0070435	Shc-EGFR complex	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:62182
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IMP	J:62182
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:62182
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:204749
Biological Process	GO:0007507	heart development	IMP	J:62182
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:81182
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:327403
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:62182
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:204749
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0006940	regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0090322	regulation of superoxide metabolic process	ISO	J:164563
Biological Process	GO:1990839	response to endothelin	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247