GO Annotations Graph

• Symbol: Sod1
• Name: superoxide dismutase 1, soluble
• ID: MGI:98351

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	IEA	J:60000
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	ISO	J:155856
Molecular Function	GO:0005507	copper ion binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043167	ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:263469
Molecular Function	GO:0005515	protein binding	IPI	J:131850
Molecular Function	GO:0005515	protein binding	IPI	J:30458
Molecular Function	GO:0030346	protein phosphatase 2B binding	ISO	J:164563
Molecular Function	GO:0030346	protein phosphatase 2B binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0004784	superoxide dismutase activity	ISO	J:155856
Molecular Function	GO:0004784	superoxide dismutase activity	ISO	J:164563
Molecular Function	GO:0004784	superoxide dismutase activity	IBA	J:265628
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:60470
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:51141
Molecular Function	GO:0004784	superoxide dismutase activity	TAS	J:79147
Molecular Function	GO:0004784	superoxide dismutase activity	TAS	J:72446
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:103045
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:94963
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:108756
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:46672
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:59502
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:6224
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:86950
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:70293
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:33472
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:82905
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:6441
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:56971
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:109001
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	TAS	J:72446
Cellular Component	GO:0005737	cytoplasm	ISO	J:142821
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:164563
Cellular Component	GO:0031045	dense core granule	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:97045
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0005758	mitochondrial intermembrane space	TAS	Reactome:R-MMU-3780959
Cellular Component	GO:0005758	mitochondrial intermembrane space	TAS	Reactome:R-MMU-3780963
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	ISO	J:155856
Cellular Component	GO:0005777	peroxisome	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0008089	anterograde axonal transport	IMP	J:165462
Biological Process	GO:0006915	apoptotic process	IMP	J:114348
Biological Process	GO:0006915	apoptotic process	IMP	J:114348
Biological Process	GO:0060088	auditory receptor cell stereocilium organization	IMP	J:118910
Biological Process	GO:0060088	auditory receptor cell stereocilium organization	IMP	J:57435
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:110486
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:114348
Biological Process	GO:0007566	embryo implantation	IMP	J:46672
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:110486
Biological Process	GO:0060047	heart contraction	ISO	J:164563
Biological Process	GO:0060047	heart contraction	IMP	J:60470
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	ISO	J:164563
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	IMP	J:86950
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:110486
Biological Process	GO:0007626	locomotory behavior	IMP	J:57385
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:108756
Biological Process	GO:0002262	myeloid cell homeostasis	IGI	J:71134
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:71134
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:114348
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:79147
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0051093	negative regulation of developmental process	IMP	J:114348
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:268032
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:118910
Biological Process	GO:2000242	negative regulation of reproductive process	IMP	J:114348
Biological Process	GO:0060052	neurofilament cytoskeleton organization	IMP	J:69136
Biological Process	GO:0060052	neurofilament cytoskeleton organization	IGI	J:69136
Biological Process	GO:0001541	ovarian follicle development	IMP	J:64299
Biological Process	GO:0032287	peripheral nervous system myelin maintenance	IMP	J:57385
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:155856
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:79147
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IGI	J:268032
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:109001
Biological Process	GO:0043087	regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:110486
Biological Process	GO:0045859	regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:86950
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:109001
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:155856
Biological Process	GO:0019430	removal of superoxide radicals	IBA	J:265628
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:109001
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:46672
Biological Process	GO:0019430	removal of superoxide radicals	IGI	J:71134
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:121616
Biological Process	GO:0019430	removal of superoxide radicals	TAS	J:72446
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:56971
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:33472
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:71134
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:60470
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:51141
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:59502
Biological Process	GO:0048678	response to axon injury	IMP	J:33472
Biological Process	GO:0046688	response to copper ion	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	IMP	J:121616
Biological Process	GO:0009408	response to heat	IMP	J:114384
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:115465
Biological Process	GO:0031667	response to nutrient levels	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IMP	J:108756
Biological Process	GO:0006979	response to oxidative stress	IMP	J:118550
Biological Process	GO:0006979	response to oxidative stress	IDA	J:79147
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:118550
Biological Process	GO:0000303	response to superoxide	ISO	J:164563
Biological Process	GO:0000303	response to superoxide	IMP	J:104300
Biological Process	GO:0000303	response to superoxide	IMP	J:51141
Biological Process	GO:0000303	response to superoxide	IMP	J:46672
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:116036
Biological Process	GO:0001895	retina homeostasis	IMP	J:111796
Biological Process	GO:0008090	retrograde axonal transport	IMP	J:165462
Biological Process	GO:0007605	sensory perception of sound	IMP	J:118910
Biological Process	GO:0007605	sensory perception of sound	IMP	J:118910
Biological Process	GO:0007605	sensory perception of sound	IMP	J:102419
Biological Process	GO:0007605	sensory perception of sound	IMP	J:56971
Biological Process	GO:0007283	spermatogenesis	IMP	J:114348
Biological Process	GO:0042554	superoxide anion generation	IDA	J:94963
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:155856
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:164563
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:70293
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:57385