GO Annotations Graph

• Symbol: Sod2
• Name: superoxide dismutase 2, mitochondrial
• ID: MGI:98352

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030145	manganese ion binding	ISO	J:155856
Molecular Function	GO:0030145	manganese ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IMP	J:93763
Molecular Function	GO:0019825	oxygen binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:190273
Molecular Function	GO:0004784	superoxide dismutase activity	ISO	J:164563
Molecular Function	GO:0004784	superoxide dismutase activity	ISO	J:155856
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:90710
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:114195
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:6704
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:135285
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:192570
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:90710
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:78889
Molecular Function	GO:0004784	superoxide dismutase activity	IDA	J:82905
Molecular Function	GO:0004784	superoxide dismutase activity	IMP	J:90710
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0042645	mitochondrial nucleoid	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:129870
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:101747
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	IDA	J:71941
Cellular Component	GO:0005739	mitochondrion	IDA	J:85083
Cellular Component	GO:0005739	mitochondrion	IDA	J:183619
Cellular Component	GO:0005739	mitochondrion	IDA	J:202975
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Biological Process	GO:0003069	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP	J:128050
Biological Process	GO:0003069	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP	J:128050
Biological Process	GO:0008637	apoptotic mitochondrial changes	IMP	J:67874
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0003032	detection of oxygen	IMP	J:67568
Biological Process	GO:0048773	erythrophore differentiation	IMP	J:93763
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:53395
Biological Process	GO:0007507	heart development	IMP	J:29899
Biological Process	GO:0030097	hemopoiesis	IMP	J:36148
Biological Process	GO:0030097	hemopoiesis	IMP	J:102322
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0042743	hydrogen peroxide metabolic process	ISO	J:155856
Biological Process	GO:0032364	intracellular oxygen homeostasis	ISO	J:164563
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:115465
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:115465
Biological Process	GO:0001889	liver development	IMP	J:123349
Biological Process	GO:0007626	locomotory behavior	IMP	J:36148
Biological Process	GO:0007005	mitochondrion organization	IMP	J:93763
Biological Process	GO:0007005	mitochondrion organization	IMP	J:36148
Biological Process	GO:0007005	mitochondrion organization	IMP	J:71457
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:93763
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:102322
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IDA	J:135285
Biological Process	GO:1902631	negative regulation of membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048666	neuron development	IMP	J:36148
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:98222
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:1905932	positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:29899
Biological Process	GO:0009791	post-embryonic development	IMP	J:36148
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:135956
Biological Process	GO:0050790	regulation of catalytic activity	IMP	J:52592
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	IMP	J:123349
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:126723
Biological Process	GO:0001836	release of cytochrome c from mitochondria	IMP	J:111592
Biological Process	GO:0001836	release of cytochrome c from mitochondria	IMP	J:115465
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:164563
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:155856
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:128050
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:128050
Biological Process	GO:0022904	respiratory electron transport chain	IMP	J:152626
Biological Process	GO:0022904	respiratory electron transport chain	IMP	J:67874
Biological Process	GO:0014823	response to activity	IMP	J:108992
Biological Process	GO:0048678	response to axon injury	IMP	J:111239
Biological Process	GO:0010332	response to gamma radiation	IGI	J:90710
Biological Process	GO:0010332	response to gamma radiation	IGI	J:90710
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:115465
Biological Process	GO:0055093	response to hyperoxia	IMP	J:74987
Biological Process	GO:0031667	response to nutrient levels	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IMP	J:152626
Biological Process	GO:0006979	response to oxidative stress	IGI	J:121138
Biological Process	GO:0006979	response to oxidative stress	IGI	J:90710
Biological Process	GO:0006979	response to oxidative stress	IMP	J:90710
Biological Process	GO:0006979	response to oxidative stress	IGI	J:152626
Biological Process	GO:0006979	response to oxidative stress	IGI	J:90710
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:93763
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:116698
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:45913
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:102322
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:52592
Biological Process	GO:0000303	response to superoxide	ISO	J:164563
Biological Process	GO:0000303	response to superoxide	IMP	J:67568
Biological Process	GO:0000303	response to superoxide	IMP	J:115465
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0042554	superoxide anion generation	IMP	J:108992
Biological Process	GO:0042554	superoxide anion generation	IMP	J:111239
Biological Process	GO:0042554	superoxide anion generation	IMP	J:111592
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:164563
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:53395
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:98222
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:78889
Biological Process	GO:0042311	vasodilation	IMP	J:98222