GO Annotations Graph

• Symbol: Sox2
• Name: SRY (sex determining region Y)-box 2
• ID: MGI:98364

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:99361
Molecular Function	GO:0003682	chromatin binding	IDA	J:99361
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:206154
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:198818
Molecular Function	GO:0003677	DNA binding	IDA	J:31475
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:240259
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:27437
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:114458
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:48465
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:116485
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:82741
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:197716
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:170271
Molecular Function	GO:0035198	miRNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:170278
Molecular Function	GO:0005515	protein binding	IPI	J:150349
Molecular Function	GO:0005515	protein binding	IPI	J:204621
Molecular Function	GO:0005515	protein binding	IPI	J:148368
Molecular Function	GO:0005515	protein binding	IPI	J:331350
Molecular Function	GO:0005515	protein binding	IPI	J:187550
Molecular Function	GO:0005515	protein binding	IPI	J:191743
Molecular Function	GO:0005515	protein binding	IPI	J:161094
Molecular Function	GO:0005515	protein binding	IPI	J:168284
Molecular Function	GO:0005515	protein binding	IPI	J:184123
Molecular Function	GO:0005515	protein binding	IPI	J:170271
Molecular Function	GO:0005515	protein binding	IPI	J:240581
Molecular Function	GO:0005515	protein binding	IPI	J:221330
Molecular Function	GO:0005515	protein binding	IPI	J:197716
Molecular Function	GO:0005515	protein binding	IPI	J:123604
Molecular Function	GO:0005515	protein binding	IPI	J:196061
Molecular Function	GO:0005515	protein binding	IPI	J:196061
Molecular Function	GO:0005515	protein binding	IPI	J:98255
Molecular Function	GO:0005515	protein binding	IPI	J:29675
Molecular Function	GO:0005515	protein binding	IPI	J:100846
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	J:100846
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:82741
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	J:100846
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:91550
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:221330
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:240259
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:136286
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:48570
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:48465
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:168146
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:27437
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:168289
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:221330
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:156932
Cellular Component	GO:0000785	chromatin	IDA	J:198818
Cellular Component	GO:0005737	cytoplasm	IDA	J:46636
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:81180
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9615549
Cellular Component	GO:0005634	nucleus	IDA	J:288268
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:175353
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:319899
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:46636
Cellular Component	GO:0005634	nucleus	IDA	J:195630
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:189004
Cellular Component	GO:0005634	nucleus	IDA	J:114458
Cellular Component	GO:0005634	nucleus	IDA	J:162095
Cellular Component	GO:0005634	nucleus	IC	J:82741
Cellular Component	GO:0005634	nucleus	IDA	J:203109
Cellular Component	GO:0005634	nucleus	IDA	J:46636
Cellular Component	GO:0005634	nucleus	IDA	J:122531
Cellular Component	GO:0005634	nucleus	IDA	J:196061
Cellular Component	GO:0005634	nucleus	IDA	J:134633
Cellular Component	GO:0005634	nucleus	IDA	J:202984
Cellular Component	GO:0005634	nucleus	IDA	J:171468
Cellular Component	GO:0005634	nucleus	IDA	J:218237
Cellular Component	GO:0005634	nucleus	IDA	J:132812
Cellular Component	GO:0005634	nucleus	IDA	J:203796
Cellular Component	GO:0005634	nucleus	IDA	J:223575
Cellular Component	GO:0005634	nucleus	IDA	J:110710
Cellular Component	GO:0005634	nucleus	IDA	J:189004
Cellular Component	GO:0005634	nucleus	IDA	J:190509
Cellular Component	GO:0005634	nucleus	IDA	J:156932
Cellular Component	GO:0005634	nucleus	IDA	J:81180
Cellular Component	GO:0005634	nucleus	IDA	J:123604
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:197716
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:123604
Biological Process	GO:0021984	adenohypophysis development	IMP	J:114458
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:51542
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:122531
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:122531
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045165	cell fate commitment	IDA	J:136180
Biological Process	GO:0001708	cell fate specification	IMP	J:81180
Biological Process	GO:0071276	cellular response to cadmium ion	IDA	J:297615
Biological Process	GO:0021987	cerebral cortex development	IMP	J:92063
Biological Process	GO:0021987	cerebral cortex development	IMP	J:92063
Biological Process	GO:0021987	cerebral cortex development	IMP	J:92063
Biological Process	GO:0021987	cerebral cortex development	IMP	J:92063
Biological Process	GO:0050973	detection of mechanical stimulus involved in equilibrioception	IMP	J:98458
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:98458
Biological Process	GO:0048852	diencephalon morphogenesis	IMP	J:92063
Biological Process	GO:0048852	diencephalon morphogenesis	IMP	J:92063
Biological Process	GO:0048568	embryonic organ development	IMP	J:122531
Biological Process	GO:0048568	embryonic organ development	IMP	J:122531
Biological Process	GO:0001714	endodermal cell fate specification	ISO	J:168146
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IDA	J:136180
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:92063
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:92063
Biological Process	GO:0010467	gene expression	IMP	J:290525
Biological Process	GO:0010467	gene expression	IMP	J:124021
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:98458
Biological Process	GO:0060235	lens induction in camera-type eye	IGI	J:119175
Biological Process	GO:0048286	lung alveolus development	IDA	J:136180
Biological Process	GO:0030539	male genitalia development	IMP	J:114458
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:129040
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:123604
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0045665	negative regulation of neuron differentiation	IDA	J:110710
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IDA	J:98255
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:48570
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IGI	J:98255
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:108452
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:108452
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:92063
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:92063
Biological Process	GO:0030182	neuron differentiation	IMP	J:108452
Biological Process	GO:0030182	neuron differentiation	IDA	J:110710
Biological Process	GO:0030182	neuron differentiation	IMP	J:108452
Biological Process	GO:0048663	neuron fate commitment	IMP	J:112945
Biological Process	GO:0097150	neuronal stem cell population maintenance	IGI	J:180508
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:110710
Biological Process	GO:0030910	olfactory placode formation	IGI	J:119175
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:98255
Biological Process	GO:0046148	pigment biosynthetic process	IMP	J:77358
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	IDA	J:136180
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:108452
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:92063
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:92063
Biological Process	GO:0045666	positive regulation of neuron differentiation	IMP	J:108452
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:110710
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:281188
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:168146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:119175
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:29675
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:99361
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:99361
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:100846
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123604
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:116485
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:27437
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:100846
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:123604
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:114458
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:116485
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:27437
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:82741
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:184001
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:184001
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:184001
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:184001
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0070848	response to growth factor	ISO	J:164563
Biological Process	GO:0010033	response to organic substance	IDA	J:136286
Biological Process	GO:0032526	response to retinoic acid	IDA	J:136286
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:108452
Biological Process	GO:0007605	sensory perception of sound	IMP	J:77358
Biological Process	GO:0035019	somatic stem cell population maintenance	ISO	J:164563
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:111554
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:164442
Biological Process	GO:0048863	stem cell differentiation	IDA	J:156932
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:240259
Biological Process	GO:0043586	tongue development	IMP	J:112945
Biological Process	GO:0001829	trophectodermal cell differentiation	IMP	J:123604
Biological Process	GO:0016055	Wnt signaling pathway	IGI	J:98255