GO Annotations Graph

• Symbol: Sox4
• Name: SRY (sex determining region Y)-box 4
• ID: MGI:98366

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:173070
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:137911
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:175304
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:197716
Molecular Function	GO:0035198	miRNA binding	IDA	J:230817
Molecular Function	GO:0005515	protein binding	IPI	J:129040
Molecular Function	GO:0005515	protein binding	IPI	J:197716
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:175338
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:137911
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:230817
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:129040
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:104307
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:197716
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0035910	ascending aorta morphogenesis	IMP	J:101156
Biological Process	GO:0003289	atrial septum primum morphogenesis	IMP	J:101156
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	IMP	J:101156
Biological Process	GO:0003211	cardiac ventricle formation	IMP	J:175338
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IMP	J:141688
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:104307
Biological Process	GO:0010467	gene expression	IDA	J:285968
Biological Process	GO:0021782	glial cell development	IMP	J:165749
Biological Process	GO:0021782	glial cell development	IMP	J:157923
Biological Process	GO:0014009	glial cell proliferation	IMP	J:157923
Biological Process	GO:0042593	glucose homeostasis	IMP	J:141688
Biological Process	GO:0007507	heart development	IMP	J:32741
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	IMP	J:232932
Biological Process	GO:0060993	kidney morphogenesis	IMP	J:101156
Biological Process	GO:0060174	limb bud formation	IMP	J:175338
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:101156
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:165749
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:175338
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045662	negative regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0001841	neural tube formation	IMP	J:175338
Biological Process	GO:0060563	neuroepithelial cell differentiation	IMP	J:165749
Biological Process	GO:0003357	noradrenergic neuron differentiation	IMP	J:157923
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP	J:129040
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	J:129040
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:175338
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175338
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175304
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:196163
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:141688
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IDA	J:319695
Biological Process	GO:0045663	positive regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:2000761	positive regulation of N-terminal peptidyl-lysine acetylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:137911
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:173070
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:48317
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:32741
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:129040
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:196163
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IMP	J:175338
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:150463
Biological Process	GO:0021510	spinal cord development	IMP	J:165749
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:165749
Biological Process	GO:0048485	sympathetic nervous system development	IMP	J:157923
Biological Process	GO:0030217	T cell differentiation	IMP	J:140312
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:101156