GO Annotations Graph

• Symbol: Sox8
• Name: SRY (sex determining region Y)-box 8
• ID: MGI:98370

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:98431
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:84530
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:60995
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:84530
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:116148
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:197716
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:175179
Molecular Function	GO:0005515	protein binding	IPI	J:197716
Molecular Function	GO:0005515	protein binding	IPI	J:84530
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:175105
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:60995
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:95755
Cellular Component	GO:0005737	cytoplasm	IMP	J:136098
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:84956
Cellular Component	GO:0005634	nucleus	IDA	J:136098
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:197716
Biological Process	GO:0060612	adipose tissue development	IMP	J:71578
Biological Process	GO:0060612	adipose tissue development	IMP	J:150382
Biological Process	GO:0060018	astrocyte fate commitment	IGI	J:154500
Biological Process	GO:0045165	cell fate commitment	IGI	J:98585
Biological Process	GO:0048469	cell maturation	IGI	J:98431
Biological Process	GO:0048469	cell maturation	IMP	J:98431
Biological Process	GO:0048484	enteric nervous system development	IMP	J:95755
Biological Process	GO:0048484	enteric nervous system development	IBA	J:265628
Biological Process	GO:0045444	fat cell differentiation	IMP	J:150382
Biological Process	GO:0001701	in utero embryonic development	IGI	J:119015
Biological Process	GO:0008584	male gonad development	IGI	J:89368
Biological Process	GO:0008584	male gonad development	IGI	J:146199
Biological Process	GO:0072289	metanephric nephron tubule formation	IGI	J:168845
Biological Process	GO:0061138	morphogenesis of a branching epithelium	IGI	J:168845
Biological Process	GO:0002009	morphogenesis of an epithelium	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:95755
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:168845
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:84956
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IDA	J:84956
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	IGI	J:154500
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0014032	neural crest cell development	IBA	J:265628
Biological Process	GO:0001755	neural crest cell migration	IMP	J:95755
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:116148
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:98084
Biological Process	GO:0007422	peripheral nervous system development	IBA	J:265628
Biological Process	GO:0007422	peripheral nervous system development	IGI	J:119015
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:168845
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175105
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175179
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:116148
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:146199
Biological Process	GO:0014015	positive regulation of gliogenesis	IMP	J:95755
Biological Process	GO:0090184	positive regulation of kidney development	IGI	J:168845
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:98084
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:60995
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:96928
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:84530
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:98431
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:98431
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010817	regulation of hormone levels	IMP	J:150382
Biological Process	GO:0072034	renal vesicle induction	IMP	J:168845
Biological Process	GO:0060041	retina development in camera-type eye	IGI	J:154500
Biological Process	GO:0060221	retinal rod cell differentiation	IGI	J:154500
Biological Process	GO:0060221	retinal rod cell differentiation	IGI	J:154500
Biological Process	GO:0060009	Sertoli cell development	IEP	J:175105
Biological Process	GO:0060009	Sertoli cell development	IGI	J:146199
Biological Process	GO:0007165	signal transduction	IMP	J:168845
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0007283	spermatogenesis	IMP	J:136098
Biological Process	GO:0007283	spermatogenesis	IGI	J:146199
Biological Process	GO:0072197	ureter morphogenesis	IGI	J:168845