GO Annotations Graph

• Symbol: Sparc
• Name: secreted acidic cysteine rich glycoprotein
• ID: MGI:98373

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:240593
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	IBA	J:265628
Molecular Function	GO:0050840	extracellular matrix binding	IBA	J:265628
Molecular Function	GO:0050840	extracellular matrix binding	IDA	J:139122
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0043167	ion binding	EXP	J:240593
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172699
Molecular Function	GO:0044183	protein folding chaperone	EXP	J:240593
Cellular Component	GO:0005604	basement membrane	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IDA	J:36211
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:240593
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:164563
Cellular Component	GO:0031092	platelet alpha granule membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0060348	bone development	IMP	J:188142
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:21055
Biological Process	GO:0030324	lung development	ISO	J:155856
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0043473	pigmentation	IMP	J:232539
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0022604	regulation of cell morphogenesis	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:139856
Biological Process	GO:0050807	regulation of synapse organization	ISO	J:155856