GO Annotations Graph

• Symbol: Spp1
• Name: secreted phosphoprotein 1
• ID: MGI:98389

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	NAS	J:114071
Molecular Function	GO:0050840	extracellular matrix binding	IBA	J:265628
Molecular Function	GO:0050840	extracellular matrix binding	IDA	J:139122
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0043167	ion binding	ISO	J:164563
Molecular Function	GO:0036094	small molecule binding	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:108608
Cellular Component	GO:0045177	apical part of cell	IDA	J:108608
Cellular Component	GO:0045177	apical part of cell	IDA	J:108608
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:108608
Cellular Component	GO:0005576	extracellular region	NAS	J:114071
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0006710	androgen catabolic process	ISO	J:164563
Biological Process	GO:0031214	biomineral tissue development	IEA	J:60000
Biological Process	GO:0030282	bone mineralization	IMP	J:111462
Biological Process	GO:0030282	bone mineralization	IMP	J:111462
Biological Process	GO:0030282	bone mineralization	IDA	J:111462
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:111462
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0071498	cellular response to fluid shear stress	IDA	J:216329
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071394	cellular response to testosterone stimulus	ISO	J:164563
Biological Process	GO:0072044	collecting duct development	IMP	J:127526
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:127526
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IMP	J:127526
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	IMP	J:127526
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IMP	J:127526
Biological Process	GO:0043066	negative regulation of apoptotic process	NAS	J:113946
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:170901
Biological Process	GO:0030593	neutrophil chemotaxis	IGI	J:170901
Biological Process	GO:0001503	ossification	IEA	J:72247
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:155856
Biological Process	GO:0001649	osteoblast differentiation	IBA	J:265628
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	IBA	J:265628
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	IDA	J:139122
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000866	positive regulation of estradiol secretion	ISO	J:164563
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0048545	response to steroid hormone	ISO	J:155856
Biological Process	GO:0033280	response to vitamin D	ISO	J:164563
Biological Process	GO:0034418	urate biosynthetic process	IMP	J:127526