GO Annotations Graph

• Symbol: Src
• Name: Rous sarcoma oncogene
• ID: MGI:98397

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0070700	BMP receptor binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0071253	connexin binding	IPI	J:240293
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:177164
Molecular Function	GO:0070851	growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IMP	J:83953
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:186090
Molecular Function	GO:0005515	protein binding	IPI	J:187578
Molecular Function	GO:0005515	protein binding	IPI	J:200503
Molecular Function	GO:0005515	protein binding	IPI	J:201301
Molecular Function	GO:0005515	protein binding	IPI	J:169070
Molecular Function	GO:0005515	protein binding	IPI	J:116386
Molecular Function	GO:0005515	protein binding	IPI	J:243445
Molecular Function	GO:0005515	protein binding	IPI	J:243445
Molecular Function	GO:0005515	protein binding	IPI	J:200428
Molecular Function	GO:0005515	protein binding	IPI	J:117509
Molecular Function	GO:0005515	protein binding	IPI	J:200397
Molecular Function	GO:0005515	protein binding	IPI	J:200362
Molecular Function	GO:0005515	protein binding	IPI	J:164711
Molecular Function	GO:0005515	protein binding	IPI	J:159091
Molecular Function	GO:0005515	protein binding	IPI	J:248210
Molecular Function	GO:0005515	protein binding	IPI	J:145752
Molecular Function	GO:0005515	protein binding	IPI	J:89495
Molecular Function	GO:0005515	protein binding	IPI	J:86955
Molecular Function	GO:0005515	protein binding	IPI	J:178186
Molecular Function	GO:0005515	protein binding	IPI	J:207686
Molecular Function	GO:0005515	protein binding	IPI	J:44192
Molecular Function	GO:0005515	protein binding	IPI	J:182942
Molecular Function	GO:0005515	protein binding	IPI	J:74533
Molecular Function	GO:0005515	protein binding	IPI	J:79952
Molecular Function	GO:0005515	protein binding	IPI	J:79952
Molecular Function	GO:0005515	protein binding	IPI	J:142139
Molecular Function	GO:0005515	protein binding	IPI	J:155567
Molecular Function	GO:0005515	protein binding	IPI	J:118143
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IMP	J:190676
Molecular Function	GO:0004672	protein kinase activity	IDA	J:79952
Molecular Function	GO:0004672	protein kinase activity	IDA	J:207686
Molecular Function	GO:0004672	protein kinase activity	IDA	J:155567
Molecular Function	GO:0004672	protein kinase activity	IDA	J:240718
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:185343
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:217289
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:281199
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-3928622
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-418870
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-420382
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9011252
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9763891
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-NUL-9726861
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:246351
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:86622
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:215922
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:217289
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0005884	actin filament	IDA	J:125001
Cellular Component	GO:0005901	caveola	IDA	J:217289
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:240293
Cellular Component	GO:0005856	cytoskeleton	IDA	J:281184
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928622
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-418870
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-420382
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5218834
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8964229
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680706
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682572
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763891
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763892
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763903
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9764150
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9817994
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9818009
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9700655
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9700661
Cellular Component	GO:1902737	dendritic filopodium	ISO	J:155856
Cellular Component	GO:0044294	dendritic growth cone	ISO	J:155856
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IMP	J:188792
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:188792
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:281184
Cellular Component	GO:0005739	mitochondrion	IDA	J:281184
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8937703
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8937738
Cellular Component	GO:0005634	nucleus	IDA	J:281184
Cellular Component	GO:0005634	nucleus	IDA	J:216329
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:216329
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:125001
Cellular Component	GO:0005886	plasma membrane	IDA	J:281184
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9011252
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9726861
Cellular Component	GO:0005886	plasma membrane	IDA	J:182942
Cellular Component	GO:0002102	podosome	IDA	J:129034
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	ISO	J:155856
Cellular Component	GO:0032587	ruffle membrane	IDA	J:125001
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:155856
Biological Process	GO:0086098	angiotensin-activated signaling pathway involved in heart process	IGI	J:215922
Biological Process	GO:0045453	bone resorption	IMP	J:89495
Biological Process	GO:0045453	bone resorption	IBA	J:265628
Biological Process	GO:0045453	bone resorption	IMP	J:151255
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:100783
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0016477	cell migration	IMP	J:95643
Biological Process	GO:0016477	cell migration	IMP	J:95643
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0071498	cellular response to fluid shear stress	IMP	J:216329
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:202378
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	IGI	J:215922
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IDA	J:125001
Biological Process	GO:0071393	cellular response to progesterone stimulus	ISO	J:155856
Biological Process	GO:0034614	cellular response to reactive oxygen species	IDA	J:207686
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IGI	J:176254
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IGI	J:176254
Biological Process	GO:0071897	DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:164563
Biological Process	GO:0030900	forebrain development	IGI	J:101055
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:219844
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060576	intestinal epithelial cell development	ISO	J:164563
Biological Process	GO:0060576	intestinal epithelial cell development	IDA	J:219844
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IGI	J:208677
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0051902	negative regulation of mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0051974	negative regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	ISO	J:155856
Biological Process	GO:0042476	odontogenesis	IMP	J:193881
Biological Process	GO:0048477	oogenesis	IMP	J:100783
Biological Process	GO:0036035	osteoclast development	IBA	J:265628
Biological Process	GO:0036035	osteoclast development	IGI	J:208677
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:246351
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:189787
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:109819
Biological Process	GO:0016310	phosphorylation	IMP	J:217289
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IGI	J:155567
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IGI	J:155567
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:155856
Biological Process	GO:0035306	positive regulation of dephosphorylation	ISO	J:164563
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:114878
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010907	positive regulation of glucose metabolic process	ISO	J:155856
Biological Process	GO:0035332	positive regulation of hippo signaling	ISO	J:164563
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ISO	J:155856
Biological Process	GO:2000394	positive regulation of lamellipodium morphogenesis	ISO	J:164563
Biological Process	GO:2000256	positive regulation of male germ cell proliferation	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:219844
Biological Process	GO:2000386	positive regulation of ovarian follicle development	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IGI	J:127491
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:155856
Biological Process	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP	J:202378
Biological Process	GO:0071803	positive regulation of podosome assembly	IDA	J:182942
Biological Process	GO:0071803	positive regulation of podosome assembly	IDA	J:211909
Biological Process	GO:0071803	positive regulation of podosome assembly	IGI	J:182942
Biological Process	GO:0071803	positive regulation of podosome assembly	IGI	J:182942
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IGI	J:127491
Biological Process	GO:0010954	positive regulation of protein processing	IGI	J:127491
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0051222	positive regulation of protein transport	ISO	J:155856
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0001545	primary ovarian follicle growth	ISO	J:155856
Biological Process	GO:0050847	progesterone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050847	progesterone receptor signaling pathway	IBA	J:265628
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	IMP	J:219236
Biological Process	GO:0006468	protein phosphorylation	IDA	J:79952
Biological Process	GO:0006468	protein phosphorylation	IDA	J:240718
Biological Process	GO:0006468	protein phosphorylation	IDA	J:100823
Biological Process	GO:2001286	regulation of caveolin-mediated endocytosis	ISO	J:164563
Biological Process	GO:0060491	regulation of cell projection assembly	IGI	J:75087
Biological Process	GO:0022407	regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:2000641	regulation of early endosome to late endosome transport	ISO	J:164563
Biological Process	GO:0010632	regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	IMP	J:100783
Biological Process	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	ISO	J:155856
Biological Process	GO:0043393	regulation of protein binding	IDA	J:180687
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0043149	stress fiber assembly	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IDA	J:75087
Biological Process	GO:0045056	transcytosis	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060065	uterus development	IMP	J:100783