GO Annotations Graph

• Symbol: Tap2
• Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
• ID: MGI:98484

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015433	ABC-type peptide antigen transporter activity	ISO	J:164563
Molecular Function	GO:0015440	ABC-type peptide transporter activity	IEA	J:72247
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0042288	MHC class I protein binding	ISO	J:155856
Molecular Function	GO:0042288	MHC class I protein binding	ISO	J:155856
Molecular Function	GO:0023029	MHC class Ib protein binding	ISO	J:164563
Molecular Function	GO:0042287	MHC protein binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	ISO	J:155856
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:155856
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:1904680	peptide transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:88804
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0046978	TAP1 binding	IPI	J:172904
Molecular Function	GO:0046978	TAP1 binding	ISO	J:164563
Molecular Function	GO:0046978	TAP1 binding	ISO	J:155856
Molecular Function	GO:0046979	TAP2 binding	ISO	J:155856
Molecular Function	GO:0046980	tapasin binding	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0042824	MHC class I peptide loading complex	ISO	J:155856
Cellular Component	GO:0042824	MHC class I peptide loading complex	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0042825	TAP complex	ISO	J:155856
Cellular Component	GO:0042825	TAP complex	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO	J:164563
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO	J:73065
Biological Process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	IDA	J:1767
Biological Process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	ISO	J:164563
Biological Process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	IDA	J:1767
Biological Process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	IMP	J:104295
Biological Process	GO:0046967	cytosol to endoplasmic reticulum transport	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0046968	peptide antigen transport	ISO	J:164563
Biological Process	GO:0015833	peptide transport	ISO	J:155856
Biological Process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I	ISO	J:155856
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	ISO	J:73065
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IMP	J:104295
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IDA	J:1767
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	ISO	J:155856
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0002237	response to molecule of bacterial origin	IMP	J:104295
Biological Process	GO:0001913	T cell mediated cytotoxicity	IDA	J:1767
Biological Process	GO:0001913	T cell mediated cytotoxicity	IMP	J:104295
Biological Process	GO:0055085	transmembrane transport	IBA	J:265628