GO Annotations Graph

• Symbol: Tbx2
• Name: T-box 2
• ID: MGI:98494

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:98516
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:98516
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:305429
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:305429
Molecular Function	GO:0005515	protein binding	IPI	J:305429
Molecular Function	GO:0005515	protein binding	IPI	J:76656
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:314219
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:314218
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:313949
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:314845
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:178974
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:305429
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:313947
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:75292
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:236373
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:313947
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:314219
Cellular Component	GO:0005634	nucleus	IDA	J:313947
Cellular Component	GO:0005634	nucleus	IDA	J:313949
Cellular Component	GO:0005634	nucleus	IDA	J:314218
Cellular Component	GO:0005634	nucleus	IDA	J:89198
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:76656
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Biological Process	GO:0035909	aorta morphogenesis	IMP	J:93610
Biological Process	GO:0006915	apoptotic process	IMP	J:305429
Biological Process	GO:0036302	atrioventricular canal development	IGI	J:181526
Biological Process	GO:0036302	atrioventricular canal development	IMP	J:93610
Biological Process	GO:1905222	atrioventricular canal morphogenesis	IGI	J:181526
Biological Process	GO:1905072	cardiac jelly development	ISO	J:164563
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	IDA	J:93610
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:93610
Biological Process	GO:0001708	cell fate specification	IBA	J:265628
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IDA	J:74741
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:305429
Biological Process	GO:0060560	developmental growth involved in morphogenesis	IMP	J:154920
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:98516
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:93610
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:93610
Biological Process	GO:0003272	endocardial cushion formation	ISO	J:164563
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:93610
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IGI	J:236373
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:305429
Biological Process	GO:0003007	heart morphogenesis	IMP	J:93610
Biological Process	GO:0060596	mammary placode formation	IGI	J:102855
Biological Process	GO:0097325	melanocyte proliferation	IMP	J:313949
Biological Process	GO:0060916	mesenchymal cell proliferation involved in lung development	IMP	J:236373
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007521	muscle cell fate determination	IMP	J:93610
Biological Process	GO:1901211	negative regulation of cardiac chamber formation	IMP	J:89198
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:74741
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:98516
Biological Process	GO:1901208	negative regulation of heart looping	IMP	J:89198
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:314218
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:314219
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:313947
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:314845
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:236373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:75292
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:305429
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:89198
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:161903
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:161903
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:76656
Biological Process	GO:0022008	neurogenesis	IMP	J:305429
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:216917
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:89198
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:93610
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:178974
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:93610
Biological Process	GO:0060465	pharynx development	IMP	J:93610
Biological Process	GO:0043474	pigment metabolic process involved in pigmentation	IMP	J:314219
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:89198
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	IMP	J:313949
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:313949
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:178974
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:75292
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:98516
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:93610
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032526	response to retinoic acid	IDA	J:178974
Biological Process	GO:0060021	roof of mouth development	IGI	J:154920
Biological Process	GO:0060021	roof of mouth development	IMP	J:154920
Biological Process	GO:0051145	smooth muscle cell differentiation	IGI	J:272619
Biological Process	GO:0072105	ureteric peristalsis	IGI	J:272619