GO Annotations Graph

• Symbol: Tbx3
• Name: T-box 3
• ID: MGI:98495

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:121230
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:232111
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:236373
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:190269
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:232111
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:158871
Cellular Component	GO:0005634	nucleus	IDA	J:137603
Cellular Component	GO:0005634	nucleus	IDA	J:155154
Cellular Component	GO:0005634	nucleus	IDA	J:137603
Cellular Component	GO:0005634	nucleus	IDA	J:155154
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Biological Process	GO:0009887	animal organ morphogenesis	ISO	J:43886
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	ISO	J:164563
Biological Process	GO:0003167	atrioventricular bundle cell differentiation	IMP	J:149014
Biological Process	GO:0036302	atrioventricular canal development	IGI	J:181526
Biological Process	GO:1905222	atrioventricular canal morphogenesis	IGI	J:181526
Biological Process	GO:0001568	blood vessel development	IMP	J:82458
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:102855
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1905072	cardiac jelly development	ISO	J:164563
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:133688
Biological Process	GO:0060923	cardiac muscle cell fate commitment	IMP	J:149014
Biological Process	GO:0001708	cell fate specification	IBA	J:265628
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IDA	J:74741
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:121230
Biological Process	GO:0042733	embryonic digit morphogenesis	ISO	J:164563
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:232111
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:204305
Biological Process	GO:0035115	embryonic forelimb morphogenesis	ISO	J:164563
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:204305
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:204305
Biological Process	GO:0003272	endocardial cushion formation	ISO	J:164563
Biological Process	GO:0030540	female genitalia development	ISO	J:164563
Biological Process	GO:0046884	follicle-stimulating hormone secretion	ISO	J:164563
Biological Process	GO:0035136	forelimb morphogenesis	ISO	J:43886
Biological Process	GO:0001947	heart looping	IMP	J:155154
Biological Process	GO:0001947	heart looping	IMP	J:129349
Biological Process	GO:0003007	heart morphogenesis	IMP	J:121230
Biological Process	GO:0061017	hepatoblast differentiation	IMP	J:134487
Biological Process	GO:0001701	in utero embryonic development	IMP	J:121230
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:305429
Biological Process	GO:0035108	limb morphogenesis	IMP	J:232111
Biological Process	GO:0035108	limb morphogenesis	IMP	J:82458
Biological Process	GO:0021761	limbic system development	IMP	J:121230
Biological Process	GO:0032275	luteinizing hormone secretion	ISO	J:164563
Biological Process	GO:0030539	male genitalia development	ISO	J:164563
Biological Process	GO:0030879	mammary gland development	ISO	J:164563
Biological Process	GO:0030879	mammary gland development	IMP	J:82458
Biological Process	GO:0030879	mammary gland development	IMP	J:102855
Biological Process	GO:0030879	mammary gland development	IMP	J:121230
Biological Process	GO:0060596	mammary placode formation	IGI	J:102855
Biological Process	GO:0060596	mammary placode formation	IDA	J:117141
Biological Process	GO:0048332	mesoderm morphogenesis	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:74741
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:134487
Biological Process	GO:0045662	negative regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IMP	J:134487
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:236373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:155154
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:121230
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:134487
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:129349
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:129349
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0061635	regulation of protein complex stability	IMP	J:232111
Biological Process	GO:0031647	regulation of protein stability	IMP	J:232111
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060021	roof of mouth development	IGI	J:154920
Biological Process	GO:0048752	semicircular canal morphogenesis	IMP	J:305429
Biological Process	GO:0060931	sinoatrial node cell development	ISO	J:164563
Biological Process	GO:0060931	sinoatrial node cell development	IMP	J:153783
Biological Process	GO:0001501	skeletal system development	ISO	J:164563
Biological Process	GO:0051145	smooth muscle cell differentiation	IGI	J:272619
Biological Process	GO:0010159	specification of animal organ position	IDA	J:117141
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:134487
Biological Process	GO:0072089	stem cell proliferation	IMP	J:134487
Biological Process	GO:0072089	stem cell proliferation	IMP	J:134487
Biological Process	GO:0072105	ureteric peristalsis	IGI	J:272619
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:149014