GO Annotations Graph

• Symbol: Hnf1a
• Name: HNF1 homeobox A
• ID: MGI:98504

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:188795
Molecular Function	GO:0003677	DNA binding	IDA	J:79507
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:111670
Molecular Function	GO:0003677	DNA binding	IDA	J:31593
Molecular Function	GO:0003677	DNA binding	IDA	J:10901
Molecular Function	GO:0003677	DNA binding	IDA	J:68032
Molecular Function	GO:0003677	DNA binding	IDA	J:49085
Molecular Function	GO:0003677	DNA binding	IDA	J:111082
Molecular Function	GO:0003677	DNA binding	ISO	J:32276
Molecular Function	GO:0003677	DNA binding	IDA	J:91695
Molecular Function	GO:0003677	DNA binding	IDA	J:33942
Molecular Function	GO:0003677	DNA binding	IDA	J:106621
Molecular Function	GO:0003677	DNA binding	IDA	J:31831
Molecular Function	GO:0003677	DNA binding	IDA	J:111226
Molecular Function	GO:0003677	DNA binding	IDA	J:95092
Molecular Function	GO:0003677	DNA binding	IDA	J:19784
Molecular Function	GO:0003677	DNA binding	IDA	J:31627
Molecular Function	GO:0003677	DNA binding	IDA	J:89193
Molecular Function	GO:0003677	DNA binding	IDA	J:94267
Molecular Function	GO:0003677	DNA binding	IDA	J:32277
Molecular Function	GO:0003677	DNA binding	IDA	J:32278
Molecular Function	GO:0003677	DNA binding	IDA	J:87162
Molecular Function	GO:0003677	DNA binding	IDA	J:68661
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:79507
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:68661
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:31627
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:106621
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:32277
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:32278
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:111226
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:32276
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:10901
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:68032
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:89193
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:31831
Molecular Function	GO:0042802	identical protein binding	IPI	J:95092
Molecular Function	GO:0042802	identical protein binding	IPI	J:32277
Molecular Function	GO:0005515	protein binding	IPI	J:271712
Molecular Function	GO:0005515	protein binding	IPI	J:106621
Molecular Function	GO:0005515	protein binding	IPI	J:182378
Molecular Function	GO:0005515	protein binding	IPI	J:32277
Molecular Function	GO:0005515	protein binding	IPI	J:111226
Molecular Function	GO:0005515	protein binding	IPI	J:32278
Molecular Function	GO:0005515	protein binding	IPI	J:95092
Molecular Function	GO:0005515	protein binding	IPI	J:95092
Molecular Function	GO:0005515	protein binding	IPI	J:31627
Molecular Function	GO:0046983	protein dimerization activity	IPI	J:163147
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:188369
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:125466
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:111226
Cellular Component	GO:0005634	nucleus	IDA	J:79507
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:113611
Cellular Component	GO:0005634	nucleus	IDA	J:31831
Cellular Component	GO:0005634	nucleus	IDA	J:79272
Cellular Component	GO:0005634	nucleus	ISO	J:32276
Cellular Component	GO:0005634	nucleus	IDA	J:111082
Cellular Component	GO:0005634	nucleus	IDA	J:122635
Cellular Component	GO:0005634	nucleus	IDA	J:98014
Cellular Component	GO:0005634	nucleus	IDA	J:31627
Cellular Component	GO:0005634	nucleus	IDA	J:32277
Cellular Component	GO:0005634	nucleus	IDA	J:31593
Cellular Component	GO:0005634	nucleus	IDA	J:68032
Cellular Component	GO:0005634	nucleus	IDA	J:10901
Cellular Component	GO:0005634	nucleus	IDA	J:49085
Cellular Component	GO:0005634	nucleus	IDA	J:32278
Cellular Component	GO:0005634	nucleus	IDA	J:12868
Cellular Component	GO:0005634	nucleus	IDA	J:106621
Cellular Component	GO:0005634	nucleus	IDA	J:95092
Cellular Component	GO:0001750	photoreceptor outer segment	IGI	J:54101
Cellular Component	GO:0045120	pronucleus	IDA	J:111226
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:87162
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:155856
Biological Process	GO:0030262	apoptotic nuclear changes	ISO	J:155856
Biological Process	GO:0015721	bile acid and bile salt transport	IMP	J:68661
Biological Process	GO:0006699	bile acid biosynthetic process	IMP	J:68661
Biological Process	GO:0001824	blastocyst development	IMP	J:111226
Biological Process	GO:0045453	bone resorption	IGI	J:98430
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071233	cellular response to leucine	ISO	J:155856
Biological Process	GO:0072752	cellular response to rapamycin	ISO	J:155856
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:68661
Biological Process	GO:0006338	chromatin remodeling	IMP	J:79507
Biological Process	GO:0006338	chromatin remodeling	IMP	J:118400
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:54101
Biological Process	GO:0006633	fatty acid biosynthetic process	IMP	J:64325
Biological Process	GO:0015908	fatty acid transport	IMP	J:64325
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IDA	J:106621
Biological Process	GO:0042593	glucose homeostasis	IMP	J:68032
Biological Process	GO:0042593	glucose homeostasis	IMP	J:48230
Biological Process	GO:0042593	glucose homeostasis	IMP	J:106621
Biological Process	GO:0046323	glucose import	ISO	J:164563
Biological Process	GO:0046323	glucose import	IDA	J:106621
Biological Process	GO:0006783	heme biosynthetic process	IMP	J:60083
Biological Process	GO:0030073	insulin secretion	ISO	J:164563
Biological Process	GO:0030073	insulin secretion	IMP	J:50287
Biological Process	GO:0030073	insulin secretion	IMP	J:91534
Biological Process	GO:0030073	insulin secretion	IMP	J:48230
Biological Process	GO:0030073	insulin secretion	IMP	J:47008
Biological Process	GO:0001889	liver development	IMP	J:47008
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:1903799	negative regulation of miRNA processing	ISO	J:155856
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0031016	pancreas development	IEA	J:72247
Biological Process	GO:0048341	paraxial mesoderm formation	IGI	J:54101
Biological Process	GO:0001890	placenta development	IGI	J:54101
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:271712
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:79507
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:113611
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:64325
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:59284
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:32276
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:68032
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:113611
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:118400
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:32278
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:89193
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:64325
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:113611
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:68661
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:10901
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:60083
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:32277
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:116521
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:68661
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:106621
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:116521
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:97550
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:31627
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:111082
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:125466
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:122635
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:94267
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	ISO	J:164563
Biological Process	GO:0008104	protein localization	IMP	J:111226
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:111226
Biological Process	GO:0046883	regulation of hormone secretion	IMP	J:47008
Biological Process	GO:1902031	regulation of NADP metabolic process	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:188369
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:49085
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IGI	J:54101
Biological Process	GO:0035623	renal glucose absorption	ISO	J:164563
Biological Process	GO:0035623	renal glucose absorption	IDA	J:106621
Biological Process	GO:0048608	reproductive structure development	IMP	J:47008
Biological Process	GO:0009749	response to glucose	IMP	J:50287
Biological Process	GO:0006979	response to oxidative stress	IMP	J:60083
Biological Process	GO:0043691	reverse cholesterol transport	IMP	J:97550
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:45399
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856