GO Annotations Graph

• Symbol: Tcf7
• Name: transcription factor 7, T cell specific
• ID: MGI:98507

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:11147
Molecular Function	GO:0003677	DNA binding	IDA	J:79002
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:79002
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IMP	J:117301
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:185349
Molecular Function	GO:0005515	protein binding	IPI	J:117301
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:185349
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:1990907	beta-catenin-TCF complex	IBA	J:265628
Cellular Component	GO:0000791	euchromatin	IDA	J:185349
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754284
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:164710
Cellular Component	GO:0005634	nucleus	IDA	J:11147
Biological Process	GO:0046632	alpha-beta T cell differentiation	IGI	J:110481
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:79002
Biological Process	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	IDA	J:79002
Biological Process	GO:0071353	cellular response to interleukin-4	ISO	J:164563
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IGI	J:90119
Biological Process	GO:0030538	embryonic genitalia morphogenesis	IGI	J:90119
Biological Process	GO:0048619	embryonic hindgut morphogenesis	IGI	J:90119
Biological Process	GO:0042492	gamma-delta T cell differentiation	IMP	J:270295
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:185349
Biological Process	GO:0021915	neural tube development	IGI	J:90119
Biological Process	GO:0042127	regulation of cell population proliferation	IDA	J:79002
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:196163
Biological Process	GO:0045586	regulation of gamma-delta T cell differentiation	IMP	J:196163
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:79002
Biological Process	GO:0033153	T cell receptor V(D)J recombination	IGI	J:110481
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:72247