GO Annotations Graph

• Symbol: Tcf3
• Name: transcription factor 3
• ID: MGI:98510

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:47702
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:155856
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:302448
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:302456
Molecular Function	GO:0003682	chromatin binding	IDA	J:146089
Molecular Function	GO:0003682	chromatin binding	IDA	J:146089
Molecular Function	GO:0003682	chromatin binding	IDA	J:139179
Molecular Function	GO:0003682	chromatin binding	IDA	J:139179
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:100494
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:210933
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:210933
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:153345
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:141327
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:110595
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:22134
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:302448
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:277651
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	ISO	J:155856
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:134786
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IPI	J:47702
Molecular Function	GO:0070888	E-box binding	IDA	J:153345
Molecular Function	GO:0070888	E-box binding	IDA	J:302448
Molecular Function	GO:0070888	E-box binding	IDA	J:277651
Molecular Function	GO:0042802	identical protein binding	IPI	J:87736
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:200299
Molecular Function	GO:0005515	protein binding	IPI	J:210057
Molecular Function	GO:0005515	protein binding	IPI	J:248229
Molecular Function	GO:0005515	protein binding	IPI	J:113904
Molecular Function	GO:0005515	protein binding	IPI	J:279055
Molecular Function	GO:0005515	protein binding	IPI	J:182496
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0005515	protein binding	IPI	J:136893
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:92783
Molecular Function	GO:0005515	protein binding	IPI	J:73675
Molecular Function	GO:0005515	protein binding	IPI	J:70381
Molecular Function	GO:0005515	protein binding	IPI	J:155127
Molecular Function	GO:0005515	protein binding	IPI	J:108218
Molecular Function	GO:0005515	protein binding	IPI	J:123002
Molecular Function	GO:0005515	protein binding	IPI	J:87736
Molecular Function	GO:0005515	protein binding	IPI	J:80030
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:134786
Molecular Function	GO:0005515	protein binding	IPI	J:155127
Molecular Function	GO:0005515	protein binding	IPI	J:94194
Molecular Function	GO:0005515	protein binding	IPI	J:155127
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:134786
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210933
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:210933
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:141327
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:94194
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:123002
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:87736
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:153345
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:125691
Molecular Function	GO:0043565	sequence-specific DNA binding	IGI	J:80030
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:136893
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:105503
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0070644	vitamin D response element binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:128085
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-448949
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-448953
Cellular Component	GO:0000786	nucleosome	IDA	J:105503
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:80041
Cellular Component	GO:0005634	nucleus	IDA	J:128085
Cellular Component	GO:0005634	nucleus	IDA	J:86307
Cellular Component	GO:0005634	nucleus	IDA	J:146089
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:94493
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:141327
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IMP	J:279055
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:47702
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:153345
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:92783
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:92783
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:125691
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:34967
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:80041
Biological Process	GO:0002326	B cell lineage commitment	ISO	J:164563
Biological Process	GO:0048468	cell development	IGI	J:125739
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	IMP	J:105503
Biological Process	GO:0030218	erythrocyte differentiation	TAS	J:110595
Biological Process	GO:0007369	gastrulation	IGI	J:211239
Biological Process	GO:0010467	gene expression	IMP	J:144049
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IBA	J:265628
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IMP	J:105503
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	ISO	J:105503
Biological Process	GO:0030098	lymphocyte differentiation	IMP	J:144049
Biological Process	GO:0001779	natural killer cell differentiation	IGI	J:125739
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0048541	Peyer's patch development	IGI	J:125739
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:80030
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:144049
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:134786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:153345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:141327
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:302448
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:210933
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:105503
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:89879
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:102167
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:132709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:132709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:109070
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:132709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:55891
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123002
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:109070
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:55891
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:155127
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:160022
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:132709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:155127
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:92783
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:277651
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:105503
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:155127
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:34967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:102167
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36282
Biological Process	GO:0050821	protein stabilization	IDA	J:94493
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:94846
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:92533
Biological Process	GO:0006355	regulation of DNA-templated transcription	IGI	J:48573
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:80041
Biological Process	GO:0006355	regulation of DNA-templated transcription	IGI	J:48573
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:105503
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:105503
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:144049
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:110595
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:105503