Tek GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tek
TEK receptor tyrosine kinase
MGI:98664

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019838	growth factor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:155217
Molecular Function	GO:0005515	protein binding	IPI	J:200516
Molecular Function	GO:0005515	protein binding	IPI	J:46939
Molecular Function	GO:0005515	protein binding	IPI	J:157867
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:20015
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-211119
Molecular Function	GO:0038023	signaling receptor activity	IPI	J:37460
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISM	J:15180
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:157867
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-211119
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:26844
Biological Process	GO:0001525	angiogenesis	TAS	J:169941
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:51336
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	TAS	J:169941
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:79305
Biological Process	GO:0007160	cell-matrix adhesion	IMP	J:79305
Biological Process	GO:0001935	endothelial cell proliferation	IMP	J:20015
Biological Process	GO:0001935	endothelial cell proliferation	IBA	J:265628
Biological Process	GO:0072012	glomerulus vasculature development	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:20015
Biological Process	GO:0060347	heart trabecula formation	IMP	J:20015
Biological Process	GO:0030097	hemopoiesis	IMP	J:51336
Biological Process	GO:0030097	hemopoiesis	IMP	J:91951
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:149670
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	J:115217
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:20015
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	IMP	J:91951
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	IDA	J:157867
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TAS	J:164086
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TAS	J:169941
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IGI	J:149670
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IDA	J:157867
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:157867
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS	J:164086
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0045765	regulation of angiogenesis	IMP	J:79305
Biological Process	GO:0030334	regulation of cell migration	IMP	J:79305
Biological Process	GO:0030334	regulation of cell migration	IDA	J:157867
Biological Process	GO:0001936	regulation of endothelial cell proliferation	TAS	J:164086
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	ISO	J:164563
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	IGI	J:157867
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0032526	response to retinoic acid	IDA	J:137480
Biological Process	GO:0002040	sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0048014	Tie signaling pathway	ISO	J:164563
Biological Process	GO:0048014	Tie signaling pathway	TAS	J:169941
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:20015

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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