GO Annotations Graph

• Symbol: Tgfb2
• Name: transforming growth factor, beta 2
• ID: MGI:98726

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	TAS	J:108007
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:91306
Molecular Function	GO:0005515	protein binding	IPI	J:203960
Molecular Function	GO:0005515	protein binding	IPI	J:88555
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	IBA	J:265628
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:108007
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005768	endosome	IDA	J:205663
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:16945
Cellular Component	GO:0043025	neuronal cell body	IDA	J:108007
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Cellular Component	GO:0099126	transforming growth factor beta complex	ISO	J:164563
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0006924	activation-induced cell death of T cells	IDA	J:18904
Biological Process	GO:0035910	ascending aorta morphogenesis	IMP	J:41682
Biological Process	GO:0060413	atrial septum morphogenesis	IMP	J:41682
Biological Process	GO:0003289	atrial septum primum morphogenesis	IMP	J:103391
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:41682
Biological Process	GO:0007411	axon guidance	IMP	J:95075
Biological Process	GO:0001568	blood vessel development	IMP	J:95075
Biological Process	GO:0001568	blood vessel development	IMP	J:95075
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:102822
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	TAS	J:169941
Biological Process	GO:0060038	cardiac muscle cell proliferation	ISO	J:164563
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	IMP	J:41682
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	TAS	J:169941
Biological Process	GO:0010002	cardioblast differentiation	ISO	J:164563
Biological Process	GO:0001502	cartilage condensation	IGI	J:30824
Biological Process	GO:0001502	cartilage condensation	IGI	J:30824
Biological Process	GO:0008219	cell death	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0045216	cell-cell junction organization	ISO	J:164563
Biological Process	GO:0030199	collagen fibril organization	ISO	J:164563
Biological Process	GO:1904888	cranial skeletal system development	IMP	J:41682
Biological Process	GO:0042416	dopamine biosynthetic process	IMP	J:108007
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:41682
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	ISO	J:155856
Biological Process	GO:0003274	endocardial cushion fusion	IMP	J:103391
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:103391
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:144180
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:95075
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:73681
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:18904
Biological Process	GO:0001654	eye development	ISO	J:164563
Biological Process	GO:0060325	face morphogenesis	IEP	J:136394
Biological Process	GO:0008347	glial cell migration	ISO	J:164563
Biological Process	GO:0001942	hair follicle development	IMP	J:56937
Biological Process	GO:0001942	hair follicle development	ISO	J:164563
Biological Process	GO:0001942	hair follicle development	IMP	J:97750
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:56937
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0007507	heart development	IMP	J:95075
Biological Process	GO:0003007	heart morphogenesis	ISO	J:164563
Biological Process	GO:0003179	heart valve morphogenesis	IMP	J:103391
Biological Process	GO:0003179	heart valve morphogenesis	IMP	J:174611
Biological Process	GO:0030097	hemopoiesis	IMP	J:87437
Biological Process	GO:0048839	inner ear development	IMP	J:41682
Biological Process	GO:0001822	kidney development	IMP	J:41682
Biological Process	GO:0008584	male gonad development	IMP	J:41682
Biological Process	GO:0003149	membranous septum morphogenesis	IMP	J:103391
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0061037	negative regulation of cartilage development	IMP	J:174611
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:144180
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:224732
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0050777	negative regulation of immune response	ISO	J:155856
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	NAS	J:56937
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	ISO	J:164563
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IMP	J:144180
Biological Process	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0003407	neural retina development	IMP	J:41682
Biological Process	GO:0001843	neural tube closure	IMP	J:41682
Biological Process	GO:0048666	neuron development	IMP	J:108007
Biological Process	GO:0048663	neuron fate commitment	IDA	J:100384
Biological Process	GO:0003151	outflow tract morphogenesis	TAS	J:169941
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:178974
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:41682
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:103391
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	IDA	J:83727
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:1904238	pericyte cell differentiation	IMP	J:256251
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:103391
Biological Process	GO:0070237	positive regulation of activation-induced cell death of T cells	IDA	J:18904
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	IMP	J:178974
Biological Process	GO:0051891	positive regulation of cardioblast differentiation	ISO	J:164563
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	IMP	J:87437
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:144180
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	IDA	J:224732
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:18904
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:136394
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:224732
Biological Process	GO:1904426	positive regulation of GTP binding	IDA	J:224732
Biological Process	GO:0045823	positive regulation of heart contraction	ISO	J:164563
Biological Process	GO:0045726	positive regulation of integrin biosynthetic process	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IDA	J:224732
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0051795	positive regulation of timing of catagen	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:41682
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IDA	J:224732
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:102822
Biological Process	GO:1902256	regulation of apoptotic process involved in outflow tract morphogenesis	IMP	J:103391
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:1903053	regulation of extracellular matrix organization	IMP	J:174611
Biological Process	GO:0051794	regulation of timing of catagen	ISO	J:164563
Biological Process	GO:0032909	regulation of transforming growth factor beta2 production	ISO	J:164563
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0032570	response to progesterone	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0062009	secondary palate development	IMP	J:41682
Biological Process	GO:0001501	skeletal system development	IMP	J:41682
Biological Process	GO:0001501	skeletal system development	IMP	J:95024
Biological Process	GO:0001501	skeletal system development	IMP	J:95024
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0048103	somatic stem cell division	IDA	J:87437
Biological Process	GO:1903701	substantia propria of cornea development	IMP	J:41682
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0060065	uterus development	IMP	J:41682
Biological Process	GO:0060412	ventricular septum morphogenesis	TAS	J:169941
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:41682
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:41682
Biological Process	GO:0042060	wound healing	ISO	J:155856