Tgfbr1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tgfbr1
transforming growth factor, beta receptor I
MGI:98728

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	IBA	J:265628
Molecular Function	GO:0016361	activin receptor activity, type I	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172195
Molecular Function	GO:0005515	protein binding	IPI	J:83727
Molecular Function	GO:0005515	protein binding	IPI	J:200409
Molecular Function	GO:0005515	protein binding	IPI	J:205663
Molecular Function	GO:0005515	protein binding	IPI	J:200401
Molecular Function	GO:0005515	protein binding	IPI	J:167938
Molecular Function	GO:0005515	protein binding	IPI	J:230032
Molecular Function	GO:0005515	protein binding	IPI	J:224716
Molecular Function	GO:0005515	protein binding	IPI	J:172195
Molecular Function	GO:0005515	protein binding	IPI	J:200401
Molecular Function	GO:0005515	protein binding	IPI	J:201272
Molecular Function	GO:0005515	protein binding	IPI	J:86237
Molecular Function	GO:0005515	protein binding	IPI	J:93750
Molecular Function	GO:0005515	protein binding	IPI	J:204744
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:289252
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:224716
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IDA	J:83727
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:155856
Molecular Function	GO:0050431	transforming growth factor beta binding	IPI	J:128350
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IDA	J:224716
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IGI	J:128350
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IDA	J:97303
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	ISO	J:155856
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	ISO	J:164563
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IBA	J:265628
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0048179	activin receptor complex	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:128350
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:205663
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:128350
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0070021	transforming growth factor beta ligand-receptor complex	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:68770
Biological Process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	IMP	J:142286
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:116889
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:116889
Biological Process	GO:0006915	apoptotic process	IMP	J:119667
Biological Process	GO:0006915	apoptotic process	IMP	J:119289
Biological Process	GO:0048844	artery morphogenesis	IMP	J:119667
Biological Process	GO:0001824	blastocyst development	IDA	J:51778
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048870	cell motility	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:149284
Biological Process	GO:0030199	collagen fibril organization	IMP	J:100586
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:142286
Biological Process	GO:0009790	embryo development	IMP	J:104918
Biological Process	GO:0009790	embryo development	IMP	J:87407
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:119289
Biological Process	GO:0043542	endothelial cell migration	IMP	J:68770
Biological Process	GO:0001935	endothelial cell proliferation	IGI	J:178359
Biological Process	GO:0001935	endothelial cell proliferation	IGI	J:178359
Biological Process	GO:1905223	epicardium morphogenesis	IMP	J:142286
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0046847	filopodium assembly	IMP	J:119289
Biological Process	GO:0008354	germ cell migration	IMP	J:100586
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:119667
Biological Process	GO:0001701	in utero embryonic development	IMP	J:68770
Biological Process	GO:0001701	in utero embryonic development	IMP	J:87407
Biological Process	GO:0001701	in utero embryonic development	IMP	J:119667
Biological Process	GO:0001822	kidney development	IGI	J:116889
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:71882
Biological Process	GO:0008584	male gonad development	IMP	J:195695
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:119289
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:119667
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	IMP	J:149284
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	ISO	J:155856
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	IGI	J:178359
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0048663	neuron fate commitment	IMP	J:100384
Biological Process	GO:0060017	parathyroid gland development	IMP	J:119667
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0060037	pharyngeal system development	IMP	J:119667
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:230021
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IGI	J:142286
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:142286
Biological Process	GO:0051491	positive regulation of filopodium assembly	IMP	J:119289
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	IGI	J:142286
Biological Process	GO:1905075	positive regulation of tight junction disassembly	IGI	J:142286
Biological Process	GO:0009791	post-embryonic development	IMP	J:119289
Biological Process	GO:0009791	post-embryonic development	IMP	J:119289
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0060043	regulation of cardiac muscle cell proliferation	IMP	J:142286
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:119289
Biological Process	GO:0010468	regulation of gene expression	IMP	J:119289
Biological Process	GO:0010468	regulation of gene expression	IMP	J:119289
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0043393	regulation of protein binding	IMP	J:109361
Biological Process	GO:0031396	regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0070723	response to cholesterol	ISO	J:164563
Biological Process	GO:0070723	response to cholesterol	IDA	J:128350
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0060021	roof of mouth development	IMP	J:119289
Biological Process	GO:0060021	roof of mouth development	IMP	J:119289
Biological Process	GO:0060021	roof of mouth development	IGI	J:116889
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IGI	J:116889
Biological Process	GO:0001501	skeletal system development	IGI	J:116889
Biological Process	GO:0048705	skeletal system morphogenesis	IGI	J:116889
Biological Process	GO:0048538	thymus development	IMP	J:119667
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:142286
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:97303
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:68770
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:178359
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:119667
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:86237
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	IMP	J:142286
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:142286
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:142286

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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