GO Annotations Graph

• Symbol: Tgfbr2
• Name: transforming growth factor, beta receptor II
• ID: MGI:98729

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	IBA	J:265628
Molecular Function	GO:0017002	activin receptor activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005539	glycosaminoglycan binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200409
Molecular Function	GO:0005515	protein binding	IPI	J:172195
Molecular Function	GO:0005515	protein binding	IPI	J:83727
Molecular Function	GO:0005515	protein binding	IPI	J:201272
Molecular Function	GO:0005515	protein binding	IPI	J:200401
Molecular Function	GO:0005515	protein binding	IPI	J:167938
Molecular Function	GO:0005515	protein binding	IPI	J:200401
Molecular Function	GO:0005515	protein binding	IPI	J:204744
Molecular Function	GO:0005515	protein binding	IPI	J:93750
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0046332	SMAD binding	IDA	J:83727
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IBA	J:265628
Molecular Function	GO:0050431	transforming growth factor beta binding	IPI	J:128350
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IBA	J:265628
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IGI	J:128350
Molecular Function	GO:0005026	transforming growth factor beta receptor activity, type II	ISO	J:155856
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	IBA	J:265628
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:128350
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:128350
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0070021	transforming growth factor beta ligand-receptor complex	ISO	J:164563
Biological Process	GO:0032147	activation of protein kinase activity	IDA	J:119289
Biological Process	GO:0009887	animal organ morphogenesis	ISO	J:155856
Biological Process	GO:0035909	aorta morphogenesis	ISO	J:164563
Biological Process	GO:0003180	aortic valve morphogenesis	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0048844	artery morphogenesis	ISO	J:164563
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:163274
Biological Process	GO:0007420	brain development	IMP	J:86042
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:119667
Biological Process	GO:0060433	bronchus development	IMP	J:143910
Biological Process	GO:0060434	bronchus morphogenesis	IMP	J:143910
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	IMP	J:163274
Biological Process	GO:0051216	cartilage development	IMP	J:136394
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0007182	common-partner SMAD protein phosphorylation	ISO	J:155856
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:86042
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:86042
Biological Process	GO:0003274	endocardial cushion fusion	IMP	J:163274
Biological Process	GO:0007369	gastrulation	IMP	J:52557
Biological Process	GO:0003430	growth plate cartilage chondrocyte growth	IMP	J:171227
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:171227
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:119667
Biological Process	GO:0007507	heart development	IMP	J:104325
Biological Process	GO:0001947	heart looping	IMP	J:137594
Biological Process	GO:0001701	in utero embryonic development	IMP	J:52557
Biological Process	GO:0001701	in utero embryonic development	IMP	J:143910
Biological Process	GO:1905317	inferior endocardial cushion morphogenesis	IMP	J:137594
Biological Process	GO:0061520	Langerhans cell differentiation	IMP	J:126147
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:71882
Biological Process	GO:1990086	lens fiber cell apoptotic process	IDA	J:71882
Biological Process	GO:0030324	lung development	IMP	J:143910
Biological Process	GO:0060463	lung lobe morphogenesis	IMP	J:143910
Biological Process	GO:0060425	lung morphogenesis	IMP	J:143910
Biological Process	GO:0060443	mammary gland morphogenesis	IMP	J:97162
Biological Process	GO:0003149	membranous septum morphogenesis	IMP	J:163274
Biological Process	GO:1990428	miRNA transport	IMP	J:249108
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218171
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:137594
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:163274
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	IGI	J:204744
Biological Process	GO:0002663	positive regulation of B cell tolerance induction	IMP	J:113553
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IMP	J:71882
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:137594
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:86042
Biological Process	GO:0051138	positive regulation of NK T cell differentiation	IMP	J:113553
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	IMP	J:113553
Biological Process	GO:0002651	positive regulation of tolerance induction to self antigen	IMP	J:113553
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	TAS	J:76521
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:97162
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:97162
Biological Process	GO:0010468	regulation of gene expression	IMP	J:171227
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:86042
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:86042
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:86042
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:86042
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:86042
Biological Process	GO:0070723	response to cholesterol	ISO	J:164563
Biological Process	GO:0070723	response to cholesterol	IDA	J:128350
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0060021	roof of mouth development	ISO	J:164563
Biological Process	GO:0062009	secondary palate development	IMP	J:86042
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:143910
Biological Process	GO:0060440	trachea formation	IMP	J:143910
Biological Process	GO:0060439	trachea morphogenesis	IMP	J:143910
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:171227
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0003186	tricuspid valve morphogenesis	IMP	J:163274
Biological Process	GO:0001570	vasculogenesis	IMP	J:86042
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:137594