GO Annotations Graph

• Symbol: Tgm2
• Name: transglutaminase 2, C polypeptide
• ID: MGI:98731

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	NAS	J:95130
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	NAS	J:55184
Molecular Function	GO:0120297	histone dopaminyltransferase activity	ISO	J:164563
Molecular Function	GO:0120295	histone serotonyltransferase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0120299	peptide histaminyltransferase activity	ISO	J:164563
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	IMP	J:67573
Molecular Function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	ISO	J:164563
Molecular Function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	IMP	J:95130
Molecular Function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	IBA	J:265628
Molecular Function	GO:0050568	protein-glutamine glutaminase activity	ISO	J:164563
Molecular Function	GO:0008483	transaminase activity	ISO	J:74326
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0005737	cytoplasm	ISA	J:18651
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	J:95130
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	TAS	J:95130
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	TAS	J:95130
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0000786	nucleosome	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0043277	apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0001974	blood vessel remodeling	ISO	J:155856
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	IMP	J:100330
Biological Process	GO:0071314	cellular response to cocaine	ISO	J:164563
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:1904015	cellular response to serotonin	ISO	J:164563
Biological Process	GO:0014046	dopamine secretion	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:95130
Biological Process	GO:0010467	gene expression	ISO	J:164563
Biological Process	GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine	ISO	J:155856
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	ISO	J:164563
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	IMP	J:211321
Biological Process	GO:0018149	peptide cross-linking	TAS	J:95130
Biological Process	GO:0018149	peptide cross-linking	ISO	J:164563
Biological Process	GO:0018149	peptide cross-linking	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISA	J:18651
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	IMP	J:95130
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	IMP	J:211321
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	ISO	J:164563
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0018277	protein deamination	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:2000425	regulation of apoptotic cell clearance	IMP	J:98998
Biological Process	GO:2000425	regulation of apoptotic cell clearance	IMP	J:109698
Biological Process	GO:2000425	regulation of apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0060662	salivary gland cavitation	IMP	J:100330