GO Annotations Graph

• Symbol: Thbs1
• Name: thrombospondin 1
• ID: MGI:98737

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0070052	collagen V binding	ISO	J:164563
Molecular Function	GO:0050840	extracellular matrix binding	IDA	J:139122
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0070051	fibrinogen binding	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:16883
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0043236	laminin binding	ISO	J:164563
Molecular Function	GO:0030169	low-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:186160
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:186160
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:81587
Cellular Component	GO:0005577	fibrinogen complex	ISO	J:164563
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:164563
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:186160
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Biological Process	GO:0048266	behavioral response to pain	IMP	J:201935
Biological Process	GO:0048514	blood vessel morphogenesis	IGI	J:159895
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071732	cellular response to nitric oxide	IMP	J:101420
Biological Process	GO:0003197	endocardial cushion development	IGI	J:159895
Biological Process	GO:0043652	engulfment of apoptotic cell	ISO	J:164563
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:136242
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:136242
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:136242
Biological Process	GO:0003417	growth plate cartilage development	IMP	J:136242
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IMP	J:100142
Biological Process	GO:0070487	monocyte aggregation	IMP	J:254528
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:101420
Biological Process	GO:0016525	negative regulation of angiogenesis	IDA	J:81587
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:101420
Biological Process	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:101420
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0002605	negative regulation of dendritic cell antigen processing and presentation	ISO	J:164563
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	ISO	J:101420
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	IMP	J:101420
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:101420
Biological Process	GO:0051918	negative regulation of fibrinolysis	ISO	J:164563
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032695	negative regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	ISO	J:164563
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	ISO	J:101420
Biological Process	GO:0010757	negative regulation of plasminogen activation	ISO	J:164563
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:159895
Biological Process	GO:0018149	peptide cross-linking	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	IDA	J:139122
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IMP	J:155187
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	ISO	J:155856
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:48446
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:186160
Biological Process	GO:0009749	response to glucose	ISO	J:164563
Biological Process	GO:0032026	response to magnesium ion	ISO	J:164563
Biological Process	GO:0009612	response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000
Biological Process	GO:0002040	sprouting angiogenesis	ISO	J:164563