GO Annotations Graph

• Symbol: Thra
• Name: thyroid hormone receptor alpha
• ID: MGI:98742

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:130306
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0140296	general transcription initiation factor binding	ISO	J:164563
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:41827
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:94471
Molecular Function	GO:0005515	protein binding	IPI	J:188568
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:94471
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:92973
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:155856
Molecular Function	GO:0017025	TBP-class protein binding	ISO	J:164563
Molecular Function	GO:0070324	thyroid hormone binding	ISO	J:164563
Molecular Function	GO:0070324	thyroid hormone binding	ISO	J:18121
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:227384
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:130306
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:314644
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:52829
Biological Process	GO:0001502	cartilage condensation	IMP	J:41827
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:132706
Biological Process	GO:0008050	female courtship behavior	IMP	J:61839
Biological Process	GO:0009755	hormone-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007611	learning or memory	IMP	J:143849
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:314644
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:72326
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:87883
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:94471
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:72326
Biological Process	GO:2000143	negative regulation of DNA-templated transcription initiation	ISO	J:164563
Biological Process	GO:0017055	negative regulation of RNA polymerase II transcription preinitiation complex assembly	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001503	ossification	IMP	J:52829
Biological Process	GO:0001503	ossification	IMP	J:41827
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IC	J:227384
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:174856
Biological Process	GO:0045925	positive regulation of female receptivity	IMP	J:61839
Biological Process	GO:0002157	positive regulation of thyroid hormone mediated signaling pathway	ISO	J:164563
Biological Process	GO:0002157	positive regulation of thyroid hormone mediated signaling pathway	IDA	J:314644
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:314644
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:227384
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:92973
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:45675
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:91511
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:85803
Biological Process	GO:0033032	regulation of myeloid cell apoptotic process	IMP	J:132706
Biological Process	GO:0002155	regulation of thyroid hormone mediated signaling pathway	IMP	J:85803
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0009409	response to cold	IMP	J:85803
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030878	thyroid gland development	IGI	J:73626
Biological Process	GO:0002154	thyroid hormone mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0060509	type I pneumocyte differentiation	IGI	J:178114
Biological Process	GO:0060509	type I pneumocyte differentiation	IGI	J:178114