GO Annotations Graph

• Symbol: Thrb
• Name: thyroid hormone receptor beta
• ID: MGI:98743

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:178620
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:130306
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:52829
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	IMP	J:159022
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:42911
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:63101
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:52829
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:51466
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:56668
Molecular Function	GO:0004879	nuclear receptor activity	IMP	J:159022
Molecular Function	GO:0005515	protein binding	IPI	J:115974
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:142045
Molecular Function	GO:0005515	protein binding	IPI	J:46724
Molecular Function	GO:0005515	protein binding	IPI	J:125047
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IEA	J:72247
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0070324	thyroid hormone binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:51466
Cellular Component	GO:0005634	nucleus	TAS	J:42911
Cellular Component	GO:0005634	nucleus	TAS	J:52829
Cellular Component	GO:0005634	nucleus	TAS	J:56668
Cellular Component	GO:0005634	nucleus	IDA	J:130306
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:52829
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	ISO	J:164563
Biological Process	GO:0008050	female courtship behavior	IMP	J:61839
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:87883
Biological Process	GO:0007621	negative regulation of female receptivity	IMP	J:61839
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:29044
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:178114
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	ISO	J:155856
Biological Process	GO:0045778	positive regulation of ossification	ISO	J:155856
Biological Process	GO:0002157	positive regulation of thyroid hormone mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:108438
Biological Process	GO:0090181	regulation of cholesterol metabolic process	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:52829
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:51466
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:142045
Biological Process	GO:0090207	regulation of triglyceride metabolic process	ISO	J:155856
Biological Process	GO:0097474	retinal cone cell apoptotic process	IMP	J:159022
Biological Process	GO:0046549	retinal cone cell development	IMP	J:159022
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	IMP	J:63101
Biological Process	GO:0002154	thyroid hormone mediated signaling pathway	IBA	J:265628
Biological Process	GO:0060509	type I pneumocyte differentiation	IGI	J:178114
Biological Process	GO:0060509	type I pneumocyte differentiation	IGI	J:178114