GO Annotations Graph

• Symbol: Timp3
• Name: tissue inhibitor of metalloproteinase 3
• ID: MGI:98754

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004857	enzyme inhibitor activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0002020	protease binding	IBA	J:265628
Cellular Component	GO:0005604	basement membrane	IDA	J:85488
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:87729
Biological Process	GO:1901706	mesenchymal cell differentiation involved in bone development	ISO	J:155856
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:1904684	negative regulation of metalloendopeptidase activity	IMP	J:223602
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	IBA	J:265628
Biological Process	GO:0009725	response to hormone	IBA	J:265628