GO Annotations Graph

• Symbol: Tnni3
• Name: troponin I, cardiac 3
• ID: MGI:98783

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0019855	calcium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0030172	troponin C binding	ISO	J:164563
Molecular Function	GO:0031014	troponin T binding	ISO	J:164563
Cellular Component	GO:0097512	cardiac myofibril	ISO	J:164563
Cellular Component	GO:1990584	cardiac Troponin complex	ISO	J:164563
Cellular Component	GO:0043292	contractile fiber	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:95322
Cellular Component	GO:0030016	myofibril	ISO	J:155856
Cellular Component	GO:0030017	sarcomere	ISO	J:95322
Cellular Component	GO:0030017	sarcomere	IDA	J:112534
Cellular Component	GO:0005861	troponin complex	ISO	J:164563
Cellular Component	GO:0005861	troponin complex	IBA	J:265628
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0060047	heart contraction	ISO	J:164563
Biological Process	GO:0007507	heart development	IDA	J:97072
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:68042
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:69919
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	ISO	J:164563
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	ISO	J:164563
Biological Process	GO:0006937	regulation of muscle contraction	IDA	J:82583
Biological Process	GO:0006940	regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	IMP	J:68042
Biological Process	GO:0003009	skeletal muscle contraction	IBA	J:265628
Biological Process	GO:0006941	striated muscle contraction	IDA	J:69919
Biological Process	GO:0006941	striated muscle contraction	IDA	J:59433
Biological Process	GO:0001570	vasculogenesis	IDA	J:97072
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	ISO	J:164563