GO Annotations Graph

• Symbol: Top2a
• Name: topoisomerase (DNA) II alpha
• ID: MGI:98790

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:164563
Molecular Function	GO:0003916	DNA topoisomerase activity	ISO	J:155856
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	ISO	J:164563
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	ISO	J:155856
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	J:3098
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	J:22850
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	J:39389
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	J:3098
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IGI	J:3098
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	J:39389
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IGI	J:110796
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:198738
Molecular Function	GO:0005515	protein binding	IPI	J:284005
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000793	condensed chromosome	IMP	J:183026
Cellular Component	GO:0000793	condensed chromosome	IDA	J:74600
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	ISO	J:164563
Cellular Component	GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	ISO	J:155856
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:39389
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:39389
Cellular Component	GO:0000228	nuclear chromosome	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	IDA	J:74600
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5228515
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:233467
Cellular Component	GO:0005634	nucleus	IDA	J:42077
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Biological Process	GO:0030263	apoptotic chromosome condensation	ISO	J:164563
Biological Process	GO:0030263	apoptotic chromosome condensation	IBA	J:265628
Biological Process	GO:0030261	chromosome condensation	IMP	J:74620
Biological Process	GO:0007059	chromosome segregation	ISO	J:164563
Biological Process	GO:0007059	chromosome segregation	IMP	J:74620
Biological Process	GO:0007059	chromosome segregation	IDA	J:22850
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006266	DNA ligation	ISO	J:164563
Biological Process	GO:0006259	DNA metabolic process	IEA	J:72247
Biological Process	GO:0006265	DNA topological change	ISO	J:164563
Biological Process	GO:0006265	DNA topological change	ISO	J:155856
Biological Process	GO:0006265	DNA topological change	IDA	J:42077
Biological Process	GO:0006265	DNA topological change	IDA	J:3098
Biological Process	GO:0040016	embryonic cleavage	IMP	J:74620
Biological Process	GO:0051309	female meiosis chromosome separation	TAS	J:233467
Biological Process	GO:0007143	female meiotic nuclear division	IMP	J:233467
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:1905463	negative regulation of DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:1777
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:217257
Biological Process	GO:0000712	resolution of meiotic recombination intermediates	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0000819	sister chromatid segregation	IBA	J:265628