GO Annotations Graph

• Symbol: Top2b
• Name: topoisomerase (DNA) II beta
• ID: MGI:98791

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003916	DNA topoisomerase activity	IEA	J:60000
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IMP	J:279373
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:170571
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:42077
Cellular Component	GO:0005634	nucleus	IDA	J:74600
Biological Process	GO:0007409	axonogenesis	IMP	J:75958
Biological Process	GO:0030183	B cell differentiation	IMP	J:279373
Biological Process	GO:0030183	B cell differentiation	ISO	J:164563
Biological Process	GO:0006259	DNA metabolic process	IEA	J:72247
Biological Process	GO:0006265	DNA topological change	ISO	J:164563
Biological Process	GO:0030900	forebrain development	IMP	J:94879
Biological Process	GO:0001764	neuron migration	IMP	J:94879
Biological Process	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO	J:164563
Biological Process	GO:0000712	resolution of meiotic recombination intermediates	IBA	J:265628
Biological Process	GO:0000819	sister chromatid segregation	IBA	J:265628