GO Annotations Graph

• Symbol: Tpm1
• Name: tropomyosin 1, alpha
• ID: MGI:98809

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	IDA	J:114084
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:245324
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0005200	structural constituent of cytoskeleton	TAS	J:32589
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0005884	actin filament	IBA	J:265628
Cellular Component	GO:0032059	bleb	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:114084
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005862	muscle thin filament tropomyosin	TAS	J:32589
Cellular Component	GO:0030016	myofibril	IDA	J:69918
Cellular Component	GO:0030016	myofibril	IDA	J:45833
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Biological Process	GO:0051693	actin filament capping	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	IBA	J:265628
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:137813
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0060048	cardiac muscle contraction	IBA	J:265628
Biological Process	GO:0009790	embryo development	IMP	J:44952
Biological Process	GO:0001701	in utero embryonic development	IMP	J:45833
Biological Process	GO:0030049	muscle filament sliding	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0003065	positive regulation of heart rate by epinephrine	IMP	J:137813
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0043462	regulation of ATP-dependent activity	ISO	J:155856
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0031529	ruffle organization	ISO	J:155856
Biological Process	GO:0045214	sarcomere organization	ISO	J:164563
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP	J:137813
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	ISO	J:164563
Biological Process	GO:0042060	wound healing	ISO	J:155856