GO Annotations Graph

• Symbol: Tfrc
• Name: transferrin receptor
• ID: MGI:98822

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	TAS	J:54107
Molecular Function	GO:0005515	protein binding	IPI	J:117182
Molecular Function	GO:0005515	protein binding	IPI	J:198162
Molecular Function	GO:0005515	protein binding	IPI	J:198162
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0004998	transferrin receptor activity	ISO	J:155856
Molecular Function	GO:0004998	transferrin receptor activity	ISO	J:164563
Molecular Function	GO:0004998	transferrin receptor activity	TAS	J:54107
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:126749
Cellular Component	GO:0009986	cell surface	ISO	J:154554
Cellular Component	GO:0009986	cell surface	IDA	J:198162
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:180119
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:94651
Cellular Component	GO:0005769	early endosome	IDA	J:239875
Cellular Component	GO:0005769	early endosome	IDA	J:239875
Cellular Component	GO:0005768	endosome	IDA	J:106641
Cellular Component	GO:0005768	endosome	IDA	J:133652
Cellular Component	GO:0005768	endosome	IDA	J:103440
Cellular Component	GO:0005768	endosome	IDA	J:90042
Cellular Component	GO:0005768	endosome	ISO	J:87965
Cellular Component	GO:0005768	endosome	IDA	J:193911
Cellular Component	GO:0005768	endosome	IDA	J:89969
Cellular Component	GO:0005768	endosome	IDA	J:90272
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163754
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:161968
Cellular Component	GO:0070062	extracellular exosome	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	IDA	J:154189
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:1990712	HFE-transferrin receptor complex	ISO	J:164563
Cellular Component	GO:1990712	HFE-transferrin receptor complex	IDA	J:117182
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:156519
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:92989
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:176914
Cellular Component	GO:0005886	plasma membrane	IDA	J:103440
Cellular Component	GO:0005886	plasma membrane	IDA	J:89969
Cellular Component	GO:0005886	plasma membrane	IDA	J:193911
Cellular Component	GO:0005886	plasma membrane	IDA	J:92989
Cellular Component	GO:0055037	recycling endosome	IDA	J:197846
Cellular Component	GO:0055037	recycling endosome	IDA	J:239875
Cellular Component	GO:0055037	recycling endosome	ISO	J:73065
Cellular Component	GO:0055037	recycling endosome	IDA	J:239875
Cellular Component	GO:0055037	recycling endosome	ISO	J:197107
Cellular Component	GO:0055038	recycling endosome membrane	ISO	J:155856
Biological Process	GO:0031668	cellular response to extracellular stimulus	TAS	J:222266
Biological Process	GO:0071281	cellular response to iron ion	TAS	J:222266
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:102391
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006879	intracellular iron ion homeostasis	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:54107
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0006826	iron ion transport	ISO	J:164563
Biological Process	GO:0006826	iron ion transport	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	ISO	J:164563
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:146763
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:231935
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0045780	positive regulation of bone resorption	IDA	J:146763
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045830	positive regulation of isotype switching	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:231935
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	IEA	J:72247
Biological Process	GO:0033572	transferrin transport	ISO	J:164563