GO Annotations Graph

• Symbol: Kdm3a
• Name: lysine (K)-specific demethylase 3A
• ID: MGI:98847

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:142786
Molecular Function	GO:0003682	chromatin binding	IDA	J:127121
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0032454	histone H3K9 demethylase activity	ISO	J:164563
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IBA	J:265628
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IMP	J:125698
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IDA	J:142786
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IMP	J:142786
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IMP	J:127121
Molecular Function	GO:0140683	histone H3K9me/H3K9me2 demethylase activity	ISO	J:164563
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:142786
Molecular Function	GO:0005515	protein binding	IPI	J:142786
Molecular Function	GO:0005515	protein binding	IPI	J:142786
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0003712	transcription coregulator activity	IDA	J:142786
Cellular Component	GO:0000785	chromatin	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:127121
Cellular Component	GO:0005737	cytoplasm	IDA	J:127121
Cellular Component	GO:0000118	histone deacetylase complex	IBA	J:265628
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:127121
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:123269
Biological Process	GO:0030521	androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0046293	formaldehyde biosynthetic process	ISO	J:164563
Biological Process	GO:0033169	histone H3-K9 demethylation	IBA	J:265628
Biological Process	GO:0016570	histone modification	IMP	J:125698
Biological Process	GO:0009755	hormone-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:147295
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:142786
Biological Process	GO:0010468	regulation of gene expression	IMP	J:125698
Biological Process	GO:2000736	regulation of stem cell differentiation	IMP	J:125698
Biological Process	GO:2000036	regulation of stem cell population maintenance	IGI	J:125698
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007290	spermatid nucleus elongation	IMP	J:127121
Biological Process	GO:0007283	spermatogenesis	IMP	J:127121