GO Annotations Graph

• Symbol: Ttn
• Name: titin
• ID: MGI:98864

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0042805	actinin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	IPI	J:137586
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051371	muscle alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:216948
Molecular Function	GO:0005515	protein binding	IPI	J:99979
Molecular Function	GO:0005515	protein binding	IPI	J:87870
Molecular Function	GO:0005515	protein binding	IPI	J:91206
Molecular Function	GO:0005515	protein binding	IPI	J:87870
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0005200	structural constituent of cytoskeleton	TAS	J:32589
Molecular Function	GO:0008307	structural constituent of muscle	ISO	J:164563
Molecular Function	GO:0008307	structural constituent of muscle	IBA	J:265628
Molecular Function	GO:0097493	structural molecule activity conferring elasticity	ISO	J:164563
Molecular Function	GO:0031433	telethonin binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0031672	A band	IDA	J:112534
Cellular Component	GO:0031672	A band	IDA	J:111284
Cellular Component	GO:0000794	condensed nuclear chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031674	I band	ISO	J:164563
Cellular Component	GO:0031674	I band	IDA	J:112534
Cellular Component	GO:0031674	I band	IDA	J:111284
Cellular Component	GO:0031430	M band	ISO	J:164563
Cellular Component	GO:0031430	M band	IBA	J:265628
Cellular Component	GO:0031430	M band	IDA	J:111284
Cellular Component	GO:0031430	M band	IDA	J:125922
Cellular Component	GO:0031430	M band	IDA	J:91206
Cellular Component	GO:0005859	muscle myosin complex	TAS	J:31001
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0030017	sarcomere	IDA	J:82868
Cellular Component	GO:0005865	striated muscle thin filament	ISO	J:164563
Cellular Component	GO:1990733	titin-telethonin complex	ISO	J:164563
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Cellular Component	GO:0030018	Z disc	IDA	J:91206
Cellular Component	GO:0030018	Z disc	ISO	J:172547
Cellular Component	GO:0030018	Z disc	IDA	J:112534
Biological Process	GO:0007512	adult heart development	IMP	J:111284
Biological Process	GO:0055013	cardiac muscle cell development	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0003300	cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:0048738	cardiac muscle tissue development	IBA	J:265628
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	ISO	J:164563
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	IMP	J:125922
Biological Process	GO:0055003	cardiac myofibril assembly	ISO	J:164563
Biological Process	GO:0055003	cardiac myofibril assembly	IMP	J:111284
Biological Process	GO:0035995	detection of muscle stretch	ISO	J:73065
Biological Process	GO:0043056	forward locomotion	IMP	J:101746
Biological Process	GO:0007507	heart development	IEP	J:51067
Biological Process	GO:0060419	heart growth	IMP	J:125922
Biological Process	GO:0003007	heart morphogenesis	IMP	J:111284
Biological Process	GO:0001701	in utero embryonic development	IMP	J:111284
Biological Process	GO:0006936	muscle contraction	IMP	J:101746
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0010737	protein kinase A signaling	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0050790	regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0045859	regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	IMP	J:200470
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563
Biological Process	GO:0045214	sarcomere organization	ISO	J:164563
Biological Process	GO:0045214	sarcomere organization	IBA	J:265628
Biological Process	GO:0045214	sarcomere organization	IMP	J:125922
Biological Process	GO:0045214	sarcomere organization	IMP	J:111284
Biological Process	GO:0045214	sarcomere organization	TAS	J:31001
Biological Process	GO:0048769	sarcomerogenesis	ISO	J:164563
Biological Process	GO:0030241	skeletal muscle myosin thick filament assembly	ISO	J:164563
Biological Process	GO:0030240	skeletal muscle thin filament assembly	ISO	J:164563
Biological Process	GO:0001756	somitogenesis	IEP	J:51067
Biological Process	GO:0055002	striated muscle cell development	IMP	J:101746
Biological Process	GO:0021591	ventricular system development	IMP	J:125922