GO Annotations Graph

• Symbol: Txn1
• Name: thioredoxin 1
• ID: MGI:98874

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:138150
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0047134	protein-disulfide reductase (NAD(P)) activity	ISO	J:164563
Molecular Function	GO:0015035	protein-disulfide reductase activity	ISO	J:164563
Molecular Function	GO:0015035	protein-disulfide reductase activity	IDA	J:138150
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:74095
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1250256
Cellular Component	GO:0005829	cytosol	IDA	J:138150
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:138150
Cellular Component	GO:0005634	nucleus	IDA	J:74095
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	IDA	J:138150
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	ISO	J:164563
Biological Process	GO:0046826	negative regulation of protein export from nucleus	IDA	J:138150
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:138150
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:138150
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0071731	response to nitric oxide	ISO	J:164563
Biological Process	GO:0009314	response to radiation	ISO	J:164563