GO Annotations Graph

• Symbol: Tyrp1
• Name: tyrosinase-related protein 1
• ID: MGI:98881

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	IPI	J:113811
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:328663
Molecular Function	GO:0005515	protein binding	IPI	J:130346
Molecular Function	GO:0005515	protein binding	IPI	J:139015
Molecular Function	GO:0005515	protein binding	IPI	J:113811
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:113811
Molecular Function	GO:0004503	tyrosinase activity	ISO	J:164563
Cellular Component	GO:0030669	clathrin-coated endocytic vesicle membrane	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0042470	melanosome	IDA	J:230050
Cellular Component	GO:0042470	melanosome	IDA	J:113811
Cellular Component	GO:0042470	melanosome	IBA	J:265628
Cellular Component	GO:0042470	melanosome	IDA	J:197308
Cellular Component	GO:0042470	melanosome	IDA	J:240360
Cellular Component	GO:0033162	melanosome membrane	IDA	J:124026
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0043438	acetoacetic acid metabolic process	IMP	J:28766
Biological Process	GO:0042438	melanin biosynthetic process	IEA	J:60000
Biological Process	GO:0006583	melanin biosynthetic process from tyrosine	TAS	J:113811
Biological Process	GO:0006582	melanin metabolic process	IMP	J:46886
Biological Process	GO:0030318	melanocyte differentiation	IBA	J:265628
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:29467
Biological Process	GO:0032438	melanosome organization	IBA	J:265628
Biological Process	GO:0032438	melanosome organization	IMP	J:46886
Biological Process	GO:0043473	pigmentation	IMP	J:29467
Biological Process	GO:0043473	pigmentation	IMP	J:12970
Biological Process	GO:0043473	pigmentation	IMP	J:12173
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	IGI	J:177116
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	ISO	J:164563