GO Annotations Graph

• Symbol: U2af2
• Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
• ID: MGI:98886

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	IPI	J:156080
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0008187	poly-pyrimidine tract binding	IBA	J:265628
Molecular Function	GO:0030628	pre-mRNA 3'-splice site binding	ISO	J:164563
Molecular Function	GO:0030628	pre-mRNA 3'-splice site binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:227344
Molecular Function	GO:0005515	protein binding	IPI	J:112647
Molecular Function	GO:0005515	protein binding	IPI	J:169297
Molecular Function	GO:0003723	RNA binding	IEA	J:72247
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Cellular Component	GO:0000243	commitment complex	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	TAS	J:156080
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	ISO	J:197742
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:319982
Cellular Component	GO:0000974	Prp19 complex	ISO	J:164563
Cellular Component	GO:0005681	spliceosomal complex	ISO	J:164563
Cellular Component	GO:0071004	U2-type prespliceosome	ISO	J:164563
Cellular Component	GO:0071004	U2-type prespliceosome	IBA	J:265628
Cellular Component	GO:0089701	U2AF complex	ISO	J:164563
Cellular Component	GO:0089701	U2AF complex	IBA	J:265628
Biological Process	GO:0006397	mRNA processing	IEA	J:72247
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0000398	mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0000398	mRNA splicing, via spliceosome	NAS	J:319982
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:164563
Biological Process	GO:0008380	RNA splicing	IDA	J:156080