GO Annotations Graph

• Symbol: Ucp1
• Name: uncoupling protein 1 (mitochondrial, proton carrier)
• ID: MGI:98894

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019003	GDP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0036041	long-chain fatty acid binding	IDA	J:189069
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	IMP	J:165368
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	ISO	J:155856
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	IDA	J:189069
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	IBA	J:265628
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	IDA	J:85229
Molecular Function	GO:0005515	protein binding	IPI	J:85229
Molecular Function	GO:0032555	purine ribonucleotide binding	IDA	J:189069
Molecular Function	GO:0022857	transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0022857	transmembrane transporter activity	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005740	mitochondrial envelope	IDA	J:85229
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:189069
Cellular Component	GO:0031966	mitochondrial membrane	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	IDA	J:236213
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:76945
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:1990845	adaptive thermogenesis	IMP	J:40053
Biological Process	GO:1990845	adaptive thermogenesis	IMP	J:235306
Biological Process	GO:1990845	adaptive thermogenesis	IBA	J:265628
Biological Process	GO:0050873	brown fat cell differentiation	IEP	J:83859
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:245403
Biological Process	GO:0070417	cellular response to cold	IDA	J:245403
Biological Process	GO:0071398	cellular response to fatty acid	IDA	J:189069
Biological Process	GO:0071398	cellular response to fatty acid	ISO	J:155856
Biological Process	GO:0032870	cellular response to hormone stimulus	IMP	J:235306
Biological Process	GO:0034614	cellular response to reactive oxygen species	IMP	J:235306
Biological Process	GO:0002024	diet induced thermogenesis	IMP	J:146646
Biological Process	GO:1990542	mitochondrial transmembrane transport	IDA	J:189069
Biological Process	GO:1990542	mitochondrial transmembrane transport	IMP	J:165368
Biological Process	GO:1990542	mitochondrial transmembrane transport	ISO	J:155856
Biological Process	GO:1990542	mitochondrial transmembrane transport	IBA	J:265628
Biological Process	GO:0006839	mitochondrial transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:244963
Biological Process	GO:1902600	proton transmembrane transport	IDA	J:189069
Biological Process	GO:1902600	proton transmembrane transport	ISO	J:164563
Biological Process	GO:1902600	proton transmembrane transport	ISO	J:155856
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IMP	J:165368
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:126723
Biological Process	GO:0009409	response to cold	IBA	J:265628
Biological Process	GO:0031667	response to nutrient levels	IMP	J:146646
Biological Process	GO:0009266	response to temperature stimulus	IMP	J:146646